中国防痨杂志2017，Vol.39Issue(7)：761-764,4.DOI:10.3969/j.issn.1000-6621.2017.07.019
含高剂量异烟肼化疗方案对药物敏感复治肺结核患者的疗效评价
Effectiveness of high-dose isoniazid regimen for treatment of TB in drug-susceptible retreated patients with pulmonary tuberculosis
摘要
Abstract
Objective To evaluate the effectiveness of high-dose isoniazid regimen for treatment of tuberculo sis (TB) in the retreated patients with TB.Methods A total of 82 drug-susceptible retreated patients were recruited into the study.They were randomly divided into high-dose isoniazid regimen group (experimental group) and standard retreatment regimen group (control group).The final sizes of the study groups were 40 and 42 for experi mental group and control group respectively.The treatment outcome,drug adverse effect and relapse of the two groups were analyzed.The quantitative data were analyzed by Chi-square test or Fisher's exact test,P＜0.05 was considered statistically significant.Results The rate of chest lesions absorption assessed through chest radiograph was 72.5％ (29/40) for experimental group and 52.4％ (22/42) for control group.There was no statistical significance between two groups (x2 =3.52,P=0.060).The rate of drug adverse reactions was 15.0％ (6/40) in experimental group which was higher than the control group (11.9 ％,5/42),but with no statistical significance between two groups (x2 =0.17,P=0.681).The cure rate and treatment success rate in experimental group were 77.5％ (31/40) and 85.0％ (34/40) respectively,which were higher than those in control group (57.1 ％,24/42;64.3％,27/42).The differences were statistically significant (x2 =3.84,P=0.049;x2 =4.61,P=0.032).The relapse rates at six months after treatment completion was 0.0％ (0/34) and 3.7％ (1/27) respectively,but there was no statistical significance (Fisher test,P =1.000).Conclusion The high-dose isoniazid regimen can effectively improve the effectiveness of retreated TB patients.关键词
结核,肺/异烟肼/剂量效应关系,药物/结果与过程评价(卫生保健)Key words
Tuberculosis, pulmonary/Isoniazid/Dose-response relationship, drug/Outcome and process assessment (health care)引用本文复制引用
陈瑜晖,郭翠弟,钟耐容,陈丽英,蔡雪珍,钟球,周琳,林伟斌,刘萍萍,温文沛,周杰,张锡林,钟倩红,何凯立,陈涛..含高剂量异烟肼化疗方案对药物敏感复治肺结核患者的疗效评价[J].中国防痨杂志,2017,39(7):761-764,4.基金项目
广东省医学科研基金项目(C2015010) （C2015010）
“十二五”国家科技重大专项(2013ZX10003009-007) （2013ZX10003009-007）
