中国免疫学杂志2017，Vol.33Issue(6)：905-909,5.DOI:10.3969/j.issn.1000-484X.2017.06.020
脐带间充质干细胞移植治疗难治性系统性红斑狼疮3年随访
3 years follow-up of refractory systemic lupus erythematosus patients with transplantation treating of umbilical cord mesenchymal stem cells
摘要
Abstract
Objective:To observe immunological indexes,the quantity of cytokine expression and clinical curative effect of umbilical cord mesenchymal stem cells between before and after the treatment of systemic lupus erythematosus patients.Methods:Selected 10 cases of SLE,on the basis of glucocorticoid and immune inhibitor treatment,intravenous injection UC-MSC of cultivating proliferation within 6 generations.Before and after treatment of UC-MSC testing the relative quantity of cytokine of CTLA-4,IL-15,IL-2,CD86,IL-17c,Foxp3,TGF-β2 which were related of immunopathogenesis of SLE.Before and after treatment to determined SLE disease activity index (SLEDAI) score and detection of blood in the urine routine,liver and kidney function,24 hours urinary protein quantitative,immunoglobulin and complement levels.Results:After treatment the relative expression value of IL-15 and IL-2 was decreased,CTLA-4 was risen.There had no significant difference with the relative expression value of CD86,IL-17c,Foxp3,TGF-β2 in before and after treatment of UC-MSC.After treatment serum complement C3 and C4 level,serum albumin,were risen.24 hour proteinuria and SLEDAI were decreased.There was no serious adverse reaction occurred,no complications related to transplantation in 10 cases.Conclusion:UC-MSC can regulate the expression of cytokines of participate in the immune response in the patients with SLE.Treatment of SLE by UC-MSC can elevate serum albumin and C3 and C4 level,reduce the 24 hours urinary protein quantity,relife kidney damage,improve clinical symptoms;UC-MSC transplantation in patients with SLE have good security;UC-MSC transplantation may be a feasible method for the treatment of SLE.关键词
脐带间充质干细胞/移植/系统性红斑狼疮Key words
Umbilical cord mesenchymal stem cells/Transplantation/Systemic lupus erythematosus分类
医药卫生引用本文复制引用
白茹,戚燕,吕昭萍,孟明耀,王晋文,侯宗柳..脐带间充质干细胞移植治疗难治性系统性红斑狼疮3年随访[J].中国免疫学杂志,2017,33(6):905-909,5.基金项目
本文为云南省科技厅社会发展科技(社会事业发展专项)2010CA004,云南省科技厅对外科技合作项目(国际合作)2013IA013. （社会事业发展专项）
