中国全科医学2017，Vol.20Issue(23)：2848-2851,4.DOI:10.3969/j.issn.1007-9572.2017.07.y13
远期冠状动脉支架植入术后患者血清生长分化因子15水平变化与支架内再狭窄及再发缺血性事件的关系研究
Long-term Correlation of Serum GDF-15 Level with Coronary In-stent Restenosis and Recurrence of Ischemic Events after Coronary Stent Implantation
摘要
Abstract
Objective To investigate the long-term correlation of serum growth differentiation factor 15(GDF15) level with the recurrence of ischemic events and coronary in-stent restenosis after coronary stent implantation.Methods Totally 162 patients with coronary stent implantation in Hangzhou Third Hospital from January 2012 to January 2015 were enrolled in this study.The patients with no-ischemia events and no-restenosis were selected as control group,and the patients with ischemic events,including angina pectoris,acute myocardial infarction and sudden cardiac death were selected as ischemic events group,and the patients with in-stent restenosis were selected as in-stent restenosis group,and the patients in in-stent restenosis group were divided into localized lesion subgroup and non-localized lesion subgroup.We observed the serum GDF15 level in patients with angina pectoris,acute myocardial infarction,sudden cardiac death and other ischemic events within one year after coronary stent implantation.At the same time,we also observed the correlation between serum GDF15 level and coronary artery restenosis for those patients who reexamined coronary angiography 9-12 months after coronary stent implantation.Results The troponin (cTnI),C-reactive protein (CRP),N-terminal brain natriuretic peptide (NT-proBNP) and GDF15 level differed significantly among the subgroups of angina pectoris,acute myocardial infarction/sudden cardiac death,and the control group (P<0.05).The cTnI,CRP,NT-proBNP,and GDF15 levels in the subgroups of angina pectoris,acute myocardial infarction/sudden cardiac death were higher than those in the control group (P<0.05).And significant differences were found in the aspects of the cTnI,CRP,NT-proBNP and GDF15 levels among the subgroups of localized lesion,non-localized lesion and the control group(P<0.05).The cTnI,CRP,NT-proBNP and GDF15 levels in the subgroups of localized lesion,non-localized lesion were higher than those in the control group (P<0.05).And in the group of patients with ischemic events and in-stent restenosis,the serum GDF15 level had no linear correlation with CRP (rs=0.170,P=0.073),but it was positively associated with cTnI,NT-proBNP levels(rs=0.242,P=0.010;rs=0.352,P<0.001).Conclusion Increased GDF15 is an important predictor for the recurrence of ischemic events and coronary in-stent restenosis after coronary stent implantation.It can be used as a clinical follow-up indicator.关键词
冠心病/生长分化因子15/冠状动脉再狭窄/心肌缺血Key words
Coronary heart disease/Growth differentiation factor 15/Coronary restenosis/Myocardial ischemia分类
医药卫生引用本文复制引用
林萍,李鹏,王琴,任谦..远期冠状动脉支架植入术后患者血清生长分化因子15水平变化与支架内再狭窄及再发缺血性事件的关系研究[J].中国全科医学,2017,20(23):2848-2851,4.基金项目
浙江省杭州市卫生科技计划课题资助(2011A023) （2011A023）
