中国全科医学2017，Vol.20Issue(24)：2984-2988,5.DOI:10.3969/j.issn.1007-9572.2017.07.y11
喉部或下咽部恶性肿瘤患者发生阻塞性睡眠呼吸暂停综合征的影响因素研究
Study on Influence Factors of Obstructive Sleep Apnea Syndrome in Patients with Laryngeal or Hypopharyngeal Cancer
摘要
Abstract
Objective To investigate the influence factors of the occurrence of obstructive sleep apnea syndrome(OSAS) in patients with laryngeal or hypopharyngeal cancer,in order to help prevent tumor growth,reduce the risk of surgery and postoperative complications and improve the quality of life of these patients.Methods Fifty patients with laryngeal or hypopharyngeal cancer who were admitted to the Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Zhengzhou University and met the inclusion criteria were selected from February to September in 2016.The clinical information of these patients were collected.All patients underwent portable monitor device.The sleep apnea hypopnea index(AHI),the minimum oxygen saturation and other data were monitored by portable sleep monitor.OSAS was diagnosed when AHI value was ≥5 times/h.The patients were divided into OSAS and non-OSAS groups according to whether the patient developed OSAS.The sex,age,body mass index(BMI),tumor location and tumor stage were compared between the two groups.And multivariate Logistic regression analysis was used to analyze the influencing factors of the occurrence of OSAS in patients with laryngeal or hypopharyngeal cancer.Results There were more males in the 50 patients,accounting for 94%.The mean age was(63.9±9.9)years and the mean BMI was(22.5±3.0)kg/m2.The tumor location:supraglottic carcinoma in 13 cases(26%),glottic laryngeal carcinoma in 25 cases(50%)and hypopharyngeal carcinoma in 12 cases(24%).The tumor stage:T1 in 20 cases(40%),T2 in 15 cases(30%),T3 in 6 cases(12%) and T4 in 9 cases(18%).The mean AHI was(15.8±11.9) times/h,the mean minimum oxygen saturation was 72.8%±10.8%.In 50 patients,there were 43 cases with AHI value ≥5 times/h,that was 43 patients in OSAS group and 7 patients in non-OSAS group.The age of patients in OSAS group was greater than that in non-OSAS group(P<0.05).Multivariate Logistic regression analysis showed that age was a risk factor of the occurrence of OSAS in patients with laryngeal or hypopharyngeal cancer〔OR=1.133,95%CI(1.023,1.255),P=0.016〕.Conclusion The incidence of OSAS is higher in patients with laryngeal or hypopharyngeal cancer.And age is a risk factor of OSAS,while BMI,tumor location and tumor stage are not related to the occurrence of OSAS.关键词
喉肿瘤/咽肿瘤/睡眠呼吸暂停,阻塞性/影响因素分析Key words
Laryngeal neoplasms/Pharyngeal neoplasms/Sleep apnea/obstructive/Root cause analysis分类
医药卫生引用本文复制引用
耿静,张鹏,胡守森,郜飞,娄卫华..喉部或下咽部恶性肿瘤患者发生阻塞性睡眠呼吸暂停综合征的影响因素研究[J].中国全科医学,2017,20(24):2984-2988,5.基金项目
国家自然科学基金资助项目(81600812) （81600812）
