中国现代医学杂志2017，Vol.27Issue(13)：14-18,5.DOI:10.3969/j.issn.1005-8982.2017.13.003
岩鹿乳康胶囊对乳腺增生大鼠乳腺组织及雌孕激素受体表达的影响
Effect of Yanlurukang Capsules on breast tissue and expressions of ER and PR in rats with hyperplasia of mammary glands
摘要
Abstract
Objective To observe the effect of Yanlurukang Capsules on the breast tissue and expressions of estrogen receptor (ER) and progesterone receptor (PR) in rats with hyperplasia of mammary glands (HMG),and to discuss the mechanism.Methods Breast hyperplasia rat model was established by intramuscular injection of estradiol benzoate and progesterone.The changes of breast tissue were observed in rats of each group.The expressions of ERα,ERβ and PR in breast tissues were detected using immunohistochemical staining.Results Yanlurukang Capsules significantly reduced the layers of mammary ductal epithelial cells and the number of acini in the experimental rats,down-regulated the expressions of ERα and PR,and enhanced the expression of ERβ.Conclusions Yanlurukang Capsules can inhibit HMG in rats,the mechanism may be related to up-regulation of ERβ expression and down-regulation of ERα and PR expressions.关键词
岩鹿乳康胶囊/乳腺增生/雌激素受体亚型/孕激素受体Key words
Yanlurukang Capsules/hyperplasia of mammary glands/ER/PR分类
医药卫生引用本文复制引用
郭宇飞,吕娟,王书勤..岩鹿乳康胶囊对乳腺增生大鼠乳腺组织及雌孕激素受体表达的影响[J].中国现代医学杂志,2017,27(13):14-18,5.基金项目
河南省中医药科学研究专项课题普通项目(No:2013ZY02036) （No:2013ZY02036）
河南省教育厅科学技术研究重点项目(No:13A360610) （No:13A360610）
