中国现代医学杂志2017，Vol.27Issue(13)：44-49,6.DOI:10.3969/j.issn.1005-8982.2017.13.009
可降解室间隔缺损封堵器的安全性与有效性的动物实验研究
Animal study on safety and effectiveness of absorbable ventricular septal occluder
陈艺丹 1潘一峰 2赵天力3
作者信息
- 1. 中南大学湘雅医院,湖南长沙410008
- 2. 中南大学湘雅医院肝胆肠研究中心,湖南长沙410008
- 3. 中南大学湘雅二医院心血管外科,湖南长沙410011
- 折叠
摘要
Abstract
Objective To evaluate the safety,biocompatibility and effectiveness of the new absorbable occluder.Methods A total of 27 adult Beagle dogs were enrolled and divided into 2 groups.Ventricular septal defect (VSD)animal models were prepared in experimental group (17 dogs) by open chest.VSD was punctured and the new absorbable occluder was implanted by guiding of transthoracic echocardiography.Laboratory examinations were done after surgery and pathological samples were obtained after euthanasia in the 3rd,6th,9th and 12th month.Then the safety and effectiveness were evaluated by comparing laboratory results,clinical and histopathological manifestations of the 2 groups.Results All dogs survived.No complications occurred.Histopathological examination showed the occluders were biocompatible and immunohistochemical examination showed epithelial cells and new vessels were growing on the occluder surface.Conclusions The new absorbable occluder has been proven to be safe,effective and biocompatible in this study.关键词
室间隔缺损/比格犬/可吸收封堵器/经胸介入/食管超声Key words
VSD/Beagle dog/absorbable occluder/transthoracic intervention/TEE分类
医药卫生引用本文复制引用
陈艺丹,潘一峰,赵天力..可降解室间隔缺损封堵器的安全性与有效性的动物实验研究[J].中国现代医学杂志,2017,27(13):44-49,6.
