中国现代医学杂志2017，Vol.27Issue(13)：74-77,4.DOI:10.3969/j.issn.1005-8982.2017.13.015
血清高迁移率族蛋白1在乙型肝炎病毒相关肝衰竭患者中的表达及其临床意义
Expression of HMGB1 in patients with hepatitis B virus-related liver failure and its significance
董瑞强 1张丹凤 2孙广荣3
作者信息
- 1. 郑州大学附属洛阳中心医院肝胆胰腺及疝外科,河南洛阳471000
- 2. 郑州大学附属洛阳中心医院眼科,河南洛阳471000
- 3. 郑州大学附属洛阳中心医院肿瘤二科,河南洛阳471000
- 折叠
摘要
Abstract
Objective To investigate the expression of serum high mobility group protein 1 (HMGB1) in patients with hepatitis B virus (HBV)-related liver failure and its clinical significance.Methods Ninety patients of HBV-related liver failure were divided into early group (group A),middle group (group B) and late group (group C) with 30 cases in each group.In addition,30 cases of healthy persons (group D) and 30 cases of chronic hepatitis B patients (group E) were used as control groups.Serum levels of biochemical indexes related to liver function and HMGB1 were detected in each group.The t test and variance analysis of independent samples were used to compare the data between the groups,and the correlations between the groups were predicted by muhiple linear regression analysis.Results The patients of the groups A,B,C and E were HMGB1 positive,their serum levels of HMGB1 were (7.54 ± 2.5),(12.05 ± 3.7),(18.69 ± 5.4) and (5.26 ± 4.0) μg/L,respectively.The patients of the group D were HMGB1 negative.The patients with HBV-related liver failure had significantly higher serum level of HMGB1 than the patients in the group E (t =2.863,P ＜ 0.05).The patients in the group C had significantly higher serum level of HMGB 1 than those in the group A (t =2.178,P ＜ 0.05).The serum HMGB1 level was positively correlated with the AST level in the patients with HBV-related liver failure (r =0.695,P ＜ 0.05).Conclusions The serum HMGB 1 level in the patients with HBV-related liver failure increases with the progression of the disease,which could partially predict the prognosis of the patients.关键词
血清高迁移率族蛋白/乙型肝炎病毒/肝衰竭/临床意义Key words
high mobility group protein/hepatitis B virus/hepatic failure/clinical value分类
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董瑞强,张丹凤,孙广荣..血清高迁移率族蛋白1在乙型肝炎病毒相关肝衰竭患者中的表达及其临床意义[J].中国现代医学杂志,2017,27(13):74-77,4.
