中国畜牧兽医2017，Vol.44Issue(7)：2009-2015,7.DOI:10.16431/j.cnki.1671-7236.2017.07.016
含β-内酰胺类药物有抗奶对犊牛生长发育和血液免疫指标的影响
Effects of β-lactam Antibiotic-contaminated Milk on Growth Performance and Blood Immune Parameters in Holstein Calves
摘要
Abstract
This experiment was conducted to investigate the effect of feeding antibiotic-contaminated milk on growth performance and blood immune parameters of Holstein calves.Eighteen calves (3 days old) with similar body weight were selected and randomly assigned into two feeding groups, which were fed bulk milk (control group) or antibiotic-contaminated milk (experimental group) until 60 days old.The experiment period lasted for 180 d.Bulk milk and antibiotic-contaminated milk were respectively collected on 10, 20, 30, 40, 50 d, which were used to detect milk composition content, E.coli and antibiotics in milk.Body weight and body measurement were severally measured on 30, 60, 90 and 180 d, and then average daily gain (ADG) was calculated.On 7, 15, 30, 60, 90 and 180 d, serum samples were collected from Holstein calves, and used for measure of immunoserologic indexes.The results showed that β-lactam antibiotic residues were 268.65 μg/L in antibiotic-contaminated milk, and the milk protein content, somatic cell counts (SCC), and E.coli number in antibiotic-contaminated milk were all significantly higher than that in bulk milk (P<0.05).Feeding antibiotic-contaminated milk significantly decreased body weight on 30 d and ADG in 60 d, as well as body length on 90 d and heart girth on 60 and 90 d (P<0.05).Compared with control group, the calves''IgA levels on 30, 60, and 90 d, IgM levels on 7 d, IgG levels on 30 and 60 d of experimental group were all significantly increased (P<0.05).Likewise, IL-2 and TNF-α levels on 15 and 30 d of experimental group were also significantly increased (P<0.05).It was concluded that feeding antibiotic-contaminated milk could obviously decrease calves''ADG of early lactation, and to some extent enhance the levels of serum immune parameters before or after weaning.关键词
β-内酰胺类药物有抗奶/荷斯坦公犊牛/生长发育/血清免疫指标Key words
β-lactam antibiotic-contaminated milk/holstein calves/growth and development/serum immunoserologic indexes分类
农业科技引用本文复制引用
韩云胜,曲永利,吴健豪,李伟,袁雪,潘琪琪,高岩..含β-内酰胺类药物有抗奶对犊牛生长发育和血液免疫指标的影响[J].中国畜牧兽医,2017,44(7):2009-2015,7.基金项目
垦区奶牛提质增效关键技术研究集成与示范(HNK135-04-02) （HNK135-04-02）
