中国畜牧兽医2017，Vol.44Issue(7)：2209-2213,5.DOI:10.16431/j.cnki.1671-7236.2017.07.044
血根碱对大鼠离体子宫平滑肌收缩的影响及其机制研究
Effect of Sanguinarine on Active Capacity of Isolated Rat Uterine Smooth Muscle in vitro and Its Mechanism
摘要
Abstract
The study was aimed to explore the effects of the sanguinarine on activity of isolated rat uterine smooth muscle in vitro.The effect of the sanguinarine on activity of the isolated myometrium of non-pregnant Sprague-Dawley rats eight weeks old was recorded by BL-420F four channels physiological recorder.Four antagonists, atropine sulfate, ranitidine hydrochloride, propranolol hydrochloride and diphenhydramine hydrochloride were used to study their mechanism, respectively.The results showed that sanguinarine and Yuan hu painkillers markedly inhibited the frequency, amplitude and activity of uterine contractions induced by oxytocin injection (P<0.05).The inhibitory effect of sanguinarine on uterine muscle contractions was blocked after using diphenhydramine hydrochloride (H1-receptor antagonist) and ranitidine hydrochloride (H2-receptor antagonist).However, after using atropine sulfate (M-receptor antagonist) and propranolol hydrochloride (β-receptor antagonist), sanguinarine also significantly inhibited the contractions of rat uterine smooth muscle (P<0.05).It was concluded that the effect of sanguinarine on activity of uterine smooth muscle in rats was mainly associated with H1 receptor or H2 receptor but not M receptor or β receptor.关键词
血根碱/大鼠/子宫平滑肌/收缩Key words
sanguinarine/rat/uterine smooth muscle/contractions分类
农业科技引用本文复制引用
贾海燕,徐婉晴,张庭华,高慧倩,王丽芳,王慧..血根碱对大鼠离体子宫平滑肌收缩的影响及其机制研究[J].中国畜牧兽医,2017,44(7):2209-2213,5.基金项目
国家级大学生创新创业训练计划项目(201510452025) （201510452025）
2016年度临沂大学教学研究与改革项目 （）
2015年度临沂大学网络在线课程(51616006) （51616006）
