中国药房2017，Vol.28Issue(21)：2901-2904,4.DOI:10.6039/j.issn.1001-0408.2017.21.06
多巴酚丁胺对感染性休克引起的急性呼吸窘迫综合征患者相关指标的影响
Effects of Dobutamine on Related Indexes of Patients with ARDS Caused by Septic Shock
摘要
Abstract
OBJECTIVE:To explore the effects of dobutamine on hemodynamics,tissue perfusion and respiratory function in patients with ARDS caused by septic shock. METHODS:Totally 26 patients with ARDS caused by septic shock were given Dobu-tamine hydrochloride injection 5 μg/(kg·min) by continuous pump for 20 min ,increasing by 5 μg/(kg·min) every 20 min to 15μg/(kg·min)for 6 h. Mean artery pressure(MAP)maintained at about 65 mmHg during continuous pump. Hemodynamic index-es [HR,MAP,cardiac output(CO),stroke volume(SV),total end diastolic volume(GEDV),intrathoracic blood volume index (ITBI),extravascular lung water index (ELWI),systemic vascular resistance index (SVRI)],tissue perfusion indexes (norepi-nephrine,urine volume,blood oxygen saturation,blood lactate)and ventilator parameter indexes(positive breathing pressure,min-ute ventilation volume,respiratory rate,peak inspiratory pressure and plateau pressure)of all patients were recorded before medica-tion,6,24,48 h after medication. RESULTS:There were no statistical significances in HR,MAP,GEDV,ITBI,blood oxygen saturation,blood lactate and respiratory rate before and after treatment (P>0.05). CO,SV,urine volume and minute ventilation volume of all patients 6,24,48 h after medication were significantly higher than before medication,and those indexes increased gradually as medication time. ELWI,SVRI,positive breathing pressure,peak inspiratory pressure and plateau pressure of all pa-tients after medication were significantly lower than before medication,and those indexes decreased gradually as medication time, with statistical significance(P<0.05). The levels of norepinephrine in all patients 24,48 h after medication were significantly low-er than before medication and 6 h after medication,with statistical significance(P<0.05);but there was no statistical significance between before medication and 6 h after medication(P>0.05). CONCLUSIONS:The early application of dobutamine ELWI,tis-sue perfusion and respiratory function in patients with ARDS caused by septic shock,and can keep hemodynamics stable.关键词
多巴酚丁胺/感染性休克/急性呼吸窘迫综合征/肺水指数/组织灌注/呼吸功能/血流动力学Key words
Dobutamine/Septic shock/ARDS/Extravascular lung water index/Tissue perfusion/Respiratory function/He-modynamics分类
医药卫生引用本文复制引用
徐凤玲,朱瑞,倪秀梅,周敏..多巴酚丁胺对感染性休克引起的急性呼吸窘迫综合征患者相关指标的影响[J].中国药房,2017,28(21):2901-2904,4.基金项目
国家自然科学基金资助项目(No.81201488) （No.81201488）
