中国药房2017，Vol.28Issue(21)：2905-2908,4.DOI:10.6039/j.issn.1001-0408.2017.21.07
甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响
Effects of Methimazole Combined with Acupoint Application on Hormone Levels and Bone Metabolism In-dexes of Patients with Hyperthyroidism
摘要
Abstract
OBJECTIVE:To investigate the effects of methimazole combined with acupoint application on hormone levels and bone metabolism indexes of patients with hyperthyroidism. METHODS:150 hyperthyroidism patients were randomly divided into group A(50 cases),group B(50 cases)and group C(50 cases). Based on routine treatment,group A was given Methimazole tab-lets orally,with initial dose of 20-40 mg,1-2 times a day;2-6 weeks later,reducing and maintaining at 2.5-10 mg if the disease condition was improved;maintaining 20-40 mg if no improvement. Group B was acupoint application,one piece,pasting on Zu-sanli,Sanyinjiao,Shenmen,Taichong,Neiguan points 1 h after breakfast. Group C received Methimazole tablets(same usage and dosage as group A)+acupoint application(same usage and dosage as group B). Treatment courses of 3 groups lasted for 2 months. The levels of TSH,FT3,FT4,T3,T4,T,E2,LH,FSH,CT,BGP and PTH were observed in 3 groups before and after treat-ment,and the occurrence of ADR was also observed. RESULTS:Before treatment,there was no statistical significance in the lev-els of above indexes among 3 groups(P>0.05). After treatment,the levels of TSH and PTH in 3 groups were significantly higher than before,and the group C was significantly higher than the group A and B. The levels of FT3,FT4,T3,T4,T,E2,LH, FSH,CT and BGP in 2 groups were significantly lower than before,and the group C was significantly lower than the group A and B;there was statistical significance (P<0.05). There was no statistical significance in each index between group A and B (P>0.05). There was no statistical significance in the incidence of ADR among 3 groups (P>0.05). CONCLUSIONS:Based on rou-tine treatment,methimazole combined with acupoint application can significantly improve the thyroid function,correct the disorder of sex hormones and abnormal bone metabolism in hyperthyroidism patient,without increasing the incidence of ADR.关键词
甲状腺功能亢进症/甲巯咪唑/穴位敷贴治疗贴/甲状腺激素/性激素/骨代谢/安全性Key words
Hyperthyroidism/Methimazole/Acupoint application/Thyroid hormone/Sex hormone/Bone metabolism/Safety分类
医药卫生引用本文复制引用
景良洪,陈琼科,宋凤萍,曾艳丽..甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响[J].中国药房,2017,28(21):2905-2908,4.基金项目
重庆市卫生和计划生育委员会中医药科技项目(No. ZY20150221) （No. ZY20150221）
