中国药房2017，Vol.28Issue(21)：2908-2911,4.DOI:10.6039/j.issn.1001-0408.2017.21.08
氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的临床观察
Clinical Observation of Flunarizine Combined with Salvianolate in the Treatment of Acute Migraine
摘要
Abstract
OBJECTIVE:To observe the clinical efficacy and safety of flunarizine combined with salvianolate in the treatment of acute migraine. METHODS:A total of 72 patients with acute migraine were randomly divided into control group(36 cases)and observation group (36 cases). Based on routine treatment,control group was given Flunarizine hydrochloride capsules orally,10 mg for 65 year-old and below once a day,5 mg for more than 65 year-old once a day. Observation group was additionally given Flunarizine hydrochloride for injection 200 mg intravenously,once a day,on the basis of control group. Both groups were treated contineously till cured or for 2 weeks. Clinical efficacy,onset time,recovery time,VAS score,frequency and duration of head-ache attack,ADR were observed in 2 groups. RESULTS:In the course of treatment,the two groups did not terminate and fall off, and all of them completed the treatment. The total response rate(97.22%)of observation group was significantly higher than that (86.11%)of control group;onset time and recovery time of observation group were both shorter than those of control group,with statistical significance (P<0.05). Before treatment,there was no statistical significance in VAS score,frequency or duration of headache attack between 2 groups (P>0.05). After treatment,VAS score,frequency and duration of headache attack in 2 groups were all significantly lower than before,and the observation group was significantly lower than the control group,with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLU-SIONS:Based on routine treatment,flunarizine hydrochloride capsules combined with Salvianolate injection show significant effica-cy for acute migraine with good safety.关键词
氟桂利嗪/丹参多酚酸盐/急性偏头痛/疗效/安全性Key words
Flunarizine/Salvianolate/Acute migraine/Therapeutic efficacy/Safety分类
医药卫生引用本文复制引用
王娟,申文娟,姚旭,郑自通,邓珊珊..氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的临床观察[J].中国药房,2017,28(21):2908-2911,4.基金项目
湖南省教育厅科学研究项目(No.16C1407) （No.16C1407）
