中国医学前沿杂志（电子版）2017，Vol.9Issue(6)：78-81,4.DOI:10.12037/YXQY.2017.06-18
孕早期胎儿超声指标在21-三体综合征中的诊断价值
Diagnostic value of ultrasonography of fetuses with trisomy 21 syndrome in early pregnancy
摘要
Abstract
Objective To investigate the diagnostic value of nuchal translucency thickness, frontomaxillary facial angle and the prenasal thickness to nasal bone length ratio in fetuses with trisomy 21 syndrome. Method From January 2016 to December 2016, 42 cases of trisomy 21 syndrome diagnosed by prenatal diagnosis in our hospital were selected as case group, and the other 80 normal fetuses were selected as control group. The nuchal translucency thickness, frontomaxillary facial angle and prenasal thickness to nasal bone length ratio of the two groups were compared. Result The nuchal translucency thickness in case group was significantly higher than that in control group (P < 0.05), and the proportion of nuchal translucency thickening was significantly greater than that in control group (P < 0.05). The frontomaxillary facial angle in case group was significantly greater than that in control group (P < 0.05), and the proportion of the frontomaxillary facial angle enlargement was significantly higher than that of control group (P < 0.05). The prenasal thickness to nasal bone length ratio in case group was significantly larger than that in control group (P < 0.05), and the prenasal thickness to nasal bone length ratio enlargement was significantly higher than that in control group (P < 0.05). The sensitivity and Youden index of the combined application of nuchal translucency thickness, nuchal translucency thickness and the prenasal thickness to nasal bone length ratio for trisomy 21 syndrome diagnostic were higher than the nuchal translucency thickness alone and the combination of nuchal translucency thickness and nuchal translucency thickness. Conclusion The nuchal translucency thickness, frontomaxillary facial angle and the prenasal thickness to nasal bone length ratio of fetuses with trisomy 21 syndrome are significantly greater than those of normal fetuses, the combination of the three indexes can improve the sensitivity and Youden index of diagnosis for trisomy 21 syndrome in early pregnancy.关键词
21-三体综合征/孕早期/超声Key words
Trisomy 21 syndrome/Early pregnancy/Ultrasonography引用本文复制引用
王焱,陈佳,段钰萍,冯齐齐..孕早期胎儿超声指标在21-三体综合征中的诊断价值[J].中国医学前沿杂志（电子版）,2017,9(6):78-81,4.基金项目
四川省卫计委科研课题(16PJ186) （16PJ186）
