中国医院用药评价与分析2017，Vol.17Issue(7)：872-875,878,5.DOI:10.14009/j.issn.1672-2124.2017.07.003
诱导化疗联合同步放化疗与单纯同步放化疗分别治疗局部晚期头颈部肿瘤的系统评价
Meta-analysis on Induction Chemotherapy Combined with Concurrent Chemotherapy and Concurrent Chemoradiotherapy Alone in Treatment of Locally Advanced Head and Neck Cancer
摘要
Abstract
OBJECTIVE:To systematically evaluate the efficacy and safety of induction chemotherapy (IC) combined with concurrent chemotherapy(CCRT) and CCRT alone in treatment of locally advanced head and neck cancer. METHODS:Relevant randomized controlled trials from Pubmed, Embase, VIP, CNKI, Wanfang data base were retrieved by computers, RevMan 5.0 software was adopted to conducted on Meta-analysis. RESULTS:Totally 8 literatures were involved, including 1 376 cases of head and neck cancer patients. According to Meta-analysis, for efficacy, there was no statistically significant difference between IC+CCRT group and CCRT group in median progression free survival (HR=0.90,95%CI=0.75-1.09,P=0.27), median overall survival (HR=1.01,95%CI=0.82-1.24,P=0.95), objective remission rate(OR=1.03,P=0.89)and disease control rate(OR=1.12,P=0.63). In terms of safety, the incidence of adverse drug reactions in IC+CCRT group was higher than that in CCRT group, with statistically significant difference (P<0.05). CONCLUSIONS:Compared with CCRT alone, IC combined with CCRT shows sufficient advantages in prolong survival time and increase total remission rate of advanced head and neck cancer, and increases the incidence of adverse drug reactions of third-level or above.关键词
头颈部肿瘤/诱导化疗/同步放化疗/Meta分析Key words
Head and neck cancer/Induction chemotherapy/Concurrent chemoradiotherapy/Meta analysis分类
医药卫生引用本文复制引用
魏佳,化怡纯,尚昆,戴岩,俞静..诱导化疗联合同步放化疗与单纯同步放化疗分别治疗局部晚期头颈部肿瘤的系统评价[J].中国医院用药评价与分析,2017,17(7):872-875,878,5.基金项目
国家自然科学基金(No.81101737) （No.81101737）
北京市"215"高层次卫生人才资助项目(No.2014-3-004) （No.2014-3-004）
