中国中西医结合杂志2017，Vol.37Issue(7)：785-788,4.DOI:10.7661/j.cjim.20170426.097
白芍总苷辅助治疗系统性硬化症的临床观察
Clinical Study of Total Glucosides of Paeony for Adjuvant Therapy of Systemic Sclerosis
摘要
Abstract
To observe the therapeutic effects and safety of total glucosides of paeony (TGP) on adjuvant therapy of systemic sclerosis (SSc).Methods Fifty SSc patients were randomly assigned to the treatment group (treated with TGP in combination with Western medicine) and the Western medicine group (treated with Western medicine alone).The treatment for all was 24 weeks.Modified Rodnan thickness score,joint function score,tooth spacing,holding power,the temperature of finger,IgG level,24 h urinary protein,and lung dispersion function were observed,and adverse reactions were monitored.Results The total effective rate was 92.0％ (23/25) in the treatment group,obviously higher than that of the control group [68.0％ (17/25)].The improvements of tooth spacing,the temperature of finger,IgG level,and 24 h urinary protein after 12 weeks of treatment were more obviously better in the treatment group than in the control group.But the aforesaid indices were more obviously improved at 24 weeks of treatment than before treatment.The initiating time was earlier in the treatment group than in control group.After 24 weeks of treatment,tooth spacing,the temperature of finger,holding power were obviously higher in the treatment group than in control group;IgG level and 24 h urinary protein were obviously lower in the treatment group than in control group.There was no significantly difference in the lung dispersion function (P ＞0.05).The incidence of liver damage was obviously lower in the treatment group than in control group [0％ (0/25) vs 20％ (5/25)].Conclusion TGP,as adjuvant therapy for SSc,could elevate the total effective rate,accelerate and optimize the efficacy at week 24,and obviously reduce the incidence of lung damage.关键词
白芍总苷/系统性硬化症/临床研究Key words
total glucosides of paeony/systemic sclerosis/clinical study引用本文复制引用
张扬,顾菲,汪悦..白芍总苷辅助治疗系统性硬化症的临床观察[J].中国中西医结合杂志,2017,37(7):785-788,4.基金项目
国家自然科学基金面上项目(No.81473607) （No.81473607）
