中国中西医结合杂志2017，Vol.37Issue(7)：789-794,6.DOI:10.7661/j.cjim.20170426.096
加味二仙汤联合心理疏导对更年期抑郁症女性单胺类神经递质的影响
Effect of Modified Erxian Decoction Combined Psychological Counseling on Monoamine Neurotransmitters of Menopausal Depression Women
摘要
Abstract
To observe the effect of Modified Erxian Decoction (MED) combined psychological counseling on the degree of depression and neurotransmitters of menopausal women with depression,and to study its possible mechanism.Methods Totally 135 menopausal depression women were randomly assigned to the Western medicine group,the integrative medical treatment group,and the integrative treatment of physical and mental modalities group,45 in each group.Patients in Western medicine group took sertraline hydrochloride,while those in integrative medical treatment group additionally took MED.Patients in integrative treatment of physical and mental modalities group were intervened by psychological counseling based on oral administration of MED and sertraline hydrochloride.The course of treatment for all was 8 weeks.The changes of Hamilton Depression Scale-17 (HAMD-17) scores and neurotransmitters in different brain areas were observed before and after treatment in each group.Resuits Eventually included cases were 39 in Western medicine group,42 in integrative medical treatment group,and 41 in integrative treatment of physical and mental modalities group.According to the HAMD-17 score,the total effective rate was 48.89％ (22/45) in the Western medicine group,78.78％ (35/45) in the integrative medical group,80.00％ (36/45) in the integrative treatment of physical and mental modalities group.Compared with the Western medicine group,the effective rate was higher in the integrative medical treatment group and the integrative treatment of physical and mental modalities group (P ＜0.05).Compared with before treatment in the same group,HAMD-17 scores of the three groups were significantly decreased (all P ＜0.01).Compared with before treatment in the same group,the level of 5HT was increased in the left occipital region and the left superior temporal region (P ＜0.05,P ＜0.01);the level of dopamine (DA) was significantly increased in the left occipital region and the left superior temporal region in the integrative treatment of physical and mental modalities group (P ＜0.05,P ＜0.01).Post-treatment NE level significantly increased in the left occipital region (P ＜ 0.01) in the integrative medical treatment group.After treatment,the NE levels in the left occipital area of the integrative medical treatment group were significantly higher than other groups (P ＜ 0.01).Conclusions MED combined psychological counseling could relieve the degree of depression in menopausal women,elevate the levels of 5-HT,DA and NE in the brain.These results suggested that MED combined psychological counseling could improve the depressive state of menopausal women possibly through elevating the levels of monoamine neurotransmitters in central nervous system.关键词
加味二仙汤/心理疏导/更年期抑郁症/单胺类神经递质Key words
Modified Erxian Decoction/psychological counseling/menopausal depression/monoamine neurotransmitter引用本文复制引用
许凤全,郑瑀,许琳洁,施蕾,张成,王彩凤,青雪梅,刘超,李健..加味二仙汤联合心理疏导对更年期抑郁症女性单胺类神经递质的影响[J].中国中西医结合杂志,2017,37(7):789-794,6.基金项目
中国中医科学院基本科研业务费自主选题项目(No.ZZ070845) （No.ZZ070845）
