中国中西医结合杂志2017，Vol.37Issue(7)：795-799,5.DOI:10.7661/j.cjim.20170426.098
补肾调经膏方对肾虚型卵巢早衰患者内分泌和免疫调节的作用
Effect of Bushen Tiaojing Paste on Endocrine and Immune Regulation of Premature Ovarian Failure Patients with Shen Deficiency
摘要
Abstract
To observe the clinical effect of Bushen Tiaojing Paste (BTR) in treatment of premature ovarian failure (POF) patients with Shen deficiency (SD),and to study its effect on patients' endocrine and immune regulation function.Methods Totally 70 POF patients with SD were assigned to two groups by random digit table.Patients in the paste group were treated with BTP,while those in the Western medicine group received hormone replacement therapy (HRT).A total of 28 days consisted of 1 course treatment for 3 consecutive courses,with follow-up of 3 months after treatment.Another 20 age-matched healthy women were selected as the healthy control group.Clinical symptoms and improvement of menstruation,sex hormone (E2,FSH,LH),and T cell subsets (CD3 +,CD4 +,CD8+)were observed before and after treatment in the two groups.Results A total of 34 patients in each group completed the study.The total effective rate of the paste group was 79.41％ (27/34),better than that of the Western medicine group (61.76％,21/34),with significant difference between the two groups (x2 =6.855,P ＜0.05).Improvement of clinical symptoms in the paste group was better than that of the Western medicine group (P ＜0.01).Improvement rate of menstruation and menstrual improvement time in the paste group were 79.41％ (27/34)and (4.09 ± 1.38)months,which were better than those of the Western medicine group [61.76％ (21/34),(4.73 ± 1.14) months] (P ＜ 0.05).And the recurrence rate was 11.76％ (4/34) in the paste group,lower than that of the Western medicine group [26.17％ (9/34),P ＞0.05].Serum E2 increased,FSH and LH decreased of the paste group,which were superior to those of the western medicine group after treatment (P ＜0.05,P ＜0.01).Serum CD4 +％ increased and CD8 +％decreased of the paste group (P ＜0.01),while CD4+％ and CD8+％ had no significant changes of the Western medicine group.There was significant difference between two groups (P ＜0.05,P ＜0.01).Conclusions The clinical effect of BTP in the treatment of POF patients with SD was significant.It could significantly improve clinical symptoms and restore normal menstrual blood,increase serum E2,and reduce FSH and LH levels.It also could regulate immune functions of human body.It is worth clinical application.关键词
补肾调经膏方/卵巢早衰/免疫调节/内分泌/肾虚型Key words
Bushen Tiaojing Paste/premature ovarian failure/immune regulation/endocrine/Shen deficiency引用本文复制引用
徐碧红,李茂清,朱勤芬,赵晓东..补肾调经膏方对肾虚型卵巢早衰患者内分泌和免疫调节的作用[J].中国中西医结合杂志,2017,37(7):795-799,5.基金项目
广东省中医药强省科研课题(No.20151130) （No.20151130）
