中国中西医结合杂志2017，Vol.37Issue(7)：863-869,7.DOI:10.7661/j.cjim.20170427.101
中草药治疗艾滋病随机对照临床试验的系统综述
Chinese Herbal Medicine for HIV/AIDS： a Systematic Review and Meta-analysis of Randomized Clinical Trials
摘要
Abstract
To assess the effectiveness and safety of Chinese herbal medicines (CHMs) for treating HIV/AIDS.Methods Randomized clinical trials (RCTs) of CHMs for HIV/AIDS were included.PubMed,Cochrane Central Register of Controlled Trials,China National Knowledge Infrastructure (CNKI),Chinese Science Journal Database,Chinese Biomedical Database,Wanfang Database were comprehensively retrieved (ended in April 2013).A self-developed data extraction form was used to extract data.The methodological quality evaluated tool recommended by Cochrane Handbook was used to evaluate the quality of trials.Revman5.1 Software was used to perform data analysis.Results Three trials were assessed as low risk of bias and the other trials as high.Compared with placebo,Ailing Granule (120 participants,2 trials) increased CD4 cell counts,MD:95.47 (95％ CI:41.52-149.41) and health-related quality of life scores:MD:4.80 (95％CI:2.63-6.96).Xiang A2 plus traditional treatment (120 participants,2 trials) increased CD4 cell counts [MD:42.92 (95％CI:4.92-80.86)],as compared with traditional treatment plus placebos.Ailing Granule plus traditional treatment (344 participants,5 trials) increased CD4 cell counts [MD:60.82 (95％ CI:27.00-94.65)],as compared with traditional treatment plus placebos.No serious adverse events were reported.Conclusions Some CHMs including Ailing Granule showed potential effects for treatment of HIV/AIDS and were not related with serious adverse reactions.However,the findings should be interpreted with caution and be verified in future studies due to poorer methodological quality of included trials and substantial heterogeneities of CHMs.关键词
中草药/艾滋病/疗效/安全性/系统评价Key words
Chinese herbal medicines/HIV/AIDS/effectiveness/safety/systematic review引用本文复制引用
张云皎,贾丽燕,牟钰洁,王丽琼,任君,刘兆兰..中草药治疗艾滋病随机对照临床试验的系统综述[J].中国中西医结合杂志,2017,37(7):863-869,7.基金项目
中国全球基金艾滋病项目2012年支持社会组织参与艾滋病防治工作项目(No.CSO-2012-研51) （No.CSO-2012-研51）
2013年教育部新世纪优秀人才支持计划项目(No.NCET-13-0694) （No.NCET-13-0694）
