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DNA甲基化与去甲基化调控肌肉发育研究进展

王波 罗海玲

动物营养学报2017,Vol.29Issue(8):2622-2629,8.
动物营养学报2017,Vol.29Issue(8):2622-2629,8.DOI:10.3969/j.issn.1006-267x.2017.08.002

DNA甲基化与去甲基化调控肌肉发育研究进展

Advances on Regulation of DNA Methylation and Demethylation on Muscle Development

王波 1罗海玲1

作者信息

  • 1. 中国农业大学动物科技学院,动物营养学国家重点实验室,北京 100193
  • 折叠

摘要

Abstract

Muscle development is a complicated biology process, which has remained largely unclear about its regulatory mechanism. The regulatory function in terms of epigenetic modifications on muscle development have turned into hot topic, and it was proved that DNA methylation and demethylation played a critical modula-tion role during myogenesis. Muscle stem cell specific-region modified by DNA methylation to regulate the my-ogenic process involves in affecting the key regulatory genes expression during muscle early development. This paper focused on the dynamic process of DNA methylation and demethylation during different stages of myo-genesis, important methyltransferases and demethylases, effects of nutrition on muscle development by DNA methylation.

关键词

DNA甲基化/去甲基化/肌肉发生//营养物质

Key words

DNA methylation/demethylation/myogenesis/enzymes/nutrient

分类

农业科技

引用本文复制引用

王波,罗海玲..DNA甲基化与去甲基化调控肌肉发育研究进展[J].动物营养学报,2017,29(8):2622-2629,8.

基金项目

国家肉羊产业技术体系( CARS-39) ( CARS-39)

动物营养学报

OA北大核心CSCDCSTPCD

1006-267X

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