广东医学2017，Vol.38Issue(16)：2465-2469,2472,6.
静态平衡功能定量分析鉴别P型和C型多系统萎缩
Differentiate multiple system atrophy of parkinsonian type from multiple system atrophy of cerebellar type by static posturography study.
摘要
Abstract
Objective To investigate the differences between patients with multiple system atrophy of parkinsonian type (MSA-P) and multiple system atrophy of cerebellar type (MSA-C) by static osturography analysis.Methods Static postural analysis was performed by the SYNAPSYS Posturography System (SPS) in 92 subjects, including 29 with MSA-P, 40 with MSA-C and 23 healthy controls.During the study, all subjects were engaged in a Sensory Organization Test (SOT), which consisted of four stance tasks of standing on a normal surface/foam support for 20 seconds with eyes open/closed separately.The amplitude of the postural sway was measured and transformed into energy by Fourier analyzer.SOT scores, the appearance of falls and typical 3-HZ postural tremors during the four tasks were recorded and compared.Energy of the three groups was also compared in different tasks, directions and frequencies.Results Compared with healthy controls, SOT scores were significantly lower in MSA groups (P<0.01).Compared with MSA-P, the vestibular scores were further reduced in MSA-C (P<0.05).Falls were more common in MSA group (especially in the MSA-C group) in the SOT4 task, and the difference between MSA-P and MSA-C was also significant (P<0.05).Typical 3-HZ postural tremor was observed in most MSA-C patients, a few MSA-P patients and none of the healthy controls.Compared with healthy controls, much more energy was consumed in every task, every direction and nearly every energy bands in MSA group.Energy of MSA-P was significantly lower than that of MSA-C mainly in the high frequency band (2 Hz-20 Hz).As the difficulty of the task increased, differences between the two groups were more common in all frequency bands.Conclusion Both MSA-P and MSA-C are characterized by severe postural dysfunction.However, typical postural tremor predominates in MSA-C, and extremely useful in the differential diagnosis of MSA-P and MSA-C.关键词
多系统萎缩/帕金森叠加综合征/姿势图/姿势性震颤Key words
multiple system atrophy/Parkinsonism plus syndromes/posturography/postural tremor引用本文复制引用
王玉周,叶锦龙,黎肖弟,郑文华,匡祖颖,陈文明,王展航,卢健军,李波,潘梦秋,徐炎..静态平衡功能定量分析鉴别P型和C型多系统萎缩[J].广东医学,2017,38(16):2465-2469,2472,6.基金项目
广东省医学科研基金立项课题(编号:B2014330) （编号:B2014330）
