海南医学院学报2017，Vol.23Issue(12)：1603-1606,4.DOI:10.13210/j.cnki.jhmu.20170519.002
白藜芦醇抑制小肠缺血再灌注继发肺损伤中P38MAPK通路及下游凋亡、炎症、氧化应激分子的表达
Resveratrol inhibits the P38MAPK pathway as well as downstream apoptosis, inflammation and oxidative stress molecule expression in secondary lung injury after intestinal ischemia-reperfusion
摘要
Abstract
Objective: To study the protective effect of resveratrol on secondary lung injury induced by intestinal ischemia reperfusion and its effect on P38MAPK pathway.Methods: Adult male SPF SD rats were divided into control group, I/R group, Res-L group, Res-M group, Res-H group, the small intestine ischemia reperfusion model was made and Res-L group, Res-M group, Res-H group were given 5.0 mg/kg, 10.0 mg/kg, 15.0 mg/kg resveratrol.P38MAPK pathway molecules and downstream apoptotic molecules, inflammatory factors and oxidative stress products in the lung were determined.Results: P38MAPK, MAPKK, MAPKKK, Fas, FasL, Caspase-8, caspase-9, NF-kB, TNF-α, IL-1β expression and ROS, MDA contents in lung tissue of I/R group were significantly higher than those of the control group;P38MAPK, MAPKK, MAPKKK, Fas, FasL, Caspase-8, caspase-9, NF-kB, TNF-α, IL-1β expression and ROS, MDA contents in lung tissue of Res-L group, Res-M group and Res-H group were significantly lower than those of I/R group.Conclusions: resveratrol can inhibit apoptosis, inflammation and oxidative stress by inhibiting the function of P38MAPK pathway, and then protect the secondary lung injury induced by intestinal ischemia reperfusion.关键词
白藜芦醇/缺血再灌注/肺损伤/P38MAPKKey words
Resveratrol/Ischemia reperfusion/Lung injury/P38MAPK分类
医药卫生引用本文复制引用
王晓光,齐晓非,李戈辉..白藜芦醇抑制小肠缺血再灌注继发肺损伤中P38MAPK通路及下游凋亡、炎症、氧化应激分子的表达[J].海南医学院学报,2017,23(12):1603-1606,4.基金项目
广东省卫生厅科研项目(JCYJ20160427192121979)It is supported by Science Research Project of Guangdong Provincial Health and Family Planning Commission (JCYJ20160427192121979). （JCYJ20160427192121979）
