海南医学院学报2017，Vol.23Issue(12)：1633-1636,4.DOI:10.13210/j.cnki.jhmu.20170607.021
mNGF注射液联合维生素D、甲钴胺对糖尿病周围神经病变患者神经功能及氧化应激的影响
Effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy
摘要
Abstract
Objective: To study the effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy.Methods: A total of 120 patients with diabetic peripheral neuropathy who were treated in our hospital between July 2012 and February 2016 were collected and randomly divided into control group (n=60) and observation group (n=60), control group were treated with vitamin D and methylamine, observation group received mNGF injection combined with vitamin D and methylamine therapy, and both therapies lasted for 8 weeks.Electromyography indexes, neurological function indexes and oxidative stress indexes were compared between two groups of patients before and after treatment.Results:: Before treatment, the differences in electromyography indexes, neurological function indexes and oxidative stress indexes were not statistically significant between two groups of patients (P>0.05).After treatment, the MCV and SCV levels of median nerve, ulnar nerve and tibial nerve in observation group were significantly higher than those in control group;serum neurological function indexes BDNF and IGF-1 contents were significantly higher than those in control group while MBP content was significantly lower than that in control group;serum oxidative stress indexes SOD, GSH and T-AOC contents were significantly higher than those in control group while MDA and AOPP contents were significantly lower than those in control group (P<0.05).Conclusions: mNGF injection combined with vitamin D and methylamine can optimize the electromyography and neurological function, and reduce the systemic oxidation stress response in patients with DPN.关键词
糖尿病周围神经病变/mNGF/神经功能/氧化应激Key words
Diabetic peripheral neuropathy/mNGF/Neurological function/Oxidation stress分类
医药卫生引用本文复制引用
李菓..mNGF注射液联合维生素D、甲钴胺对糖尿病周围神经病变患者神经功能及氧化应激的影响[J].海南医学院学报,2017,23(12):1633-1636,4.基金项目
自贡市科技局课题项目(2015S07)It is supported by the Project of Zigong Science and Technology Bureau (2015S07). （2015S07）
