海南医学院学报2017，Vol.23Issue(12)：1679-1681,1685,4.DOI:10.13210/j.cnki.jhmu.20170607.013
甲状腺癌患者血清甲状腺球蛋白以及抗甲状腺球蛋白抗体水平与肺转移、骨转移的相关性研究
Correlation of serum thyroglobulin and anti-thyroglobulin antibody levels with pulmonary metastasis and bone metastasis in patients with thyroid cancer
摘要
Abstract
Objective: To study the correlation of serum thyroglobulin (TG) and anti-thyroglobulin antibody (TGAb) levels with pulmonary metastasis and bone metastasis in patients with thyroid cancer. Methods: Patients with thyroid cancer who underwent surgical resection in our hospital were selected as the research subjects, and the patients without distant metastasis, with pulmonary metastasis and with bone metastasis were screened and enrolled in non-metastasis group, pulmonary metastasis group and bone metastasis group respectively. Serum was collected to determine the levels of TG and TGAb, and metastatic lesion tissue was collected to determine the expression proliferation-related molecules Bcl-2, Skp-2, caspase-3 and p27 as well as invasion molecules S100A4, MMP2, MMP13, SATB1 and Vimentin.Results: The positive rates of serum TGAb and TG of pulmonary metastasis group and bone metastasis group were significantly higher than those of non-metastasis group; S100A4, MMP2, MMP13, SATB1, Vimentin, Bcl-2 and Skp-2 mRNA contents in metastatic lesions of patients with positive serum TG and TGAb were significantly higher than those of patients with negative serum TG and TGAb while caspase-3 and p27 mRNA contents were significantly lower than those of patients with negative serum TG and TGAb.Conclusions: The increase of serum TG and TGAb contents is associated with the pulmonary metastasis and bone metastasis after thyroid carcinoma surgery, and has promoting effect on the proliferation and invasion of cancer cells in metastatic lesions.关键词
甲状腺癌/甲状腺球蛋白/转移/增殖/侵袭Key words
Thyroid cancer/Thyroglobulin/metastasis/Proliferation/Invasion分类
医药卫生引用本文复制引用
田军军,陶然,沈银峰,夏绍友,李晨..甲状腺癌患者血清甲状腺球蛋白以及抗甲状腺球蛋白抗体水平与肺转移、骨转移的相关性研究[J].海南医学院学报,2017,23(12):1679-1681,1685,4.基金项目
解放军总医院科技创新苗圃基金项目(15KMM37)It is supported by Scientific and Technological Innovation Nursery Foundation of PLA General Hospital (15KMM37). （15KMM37）
