中国现代医学杂志2017，Vol.27Issue(17)：40-44,5.DOI:10.3969/j.issn.1005-8982.2017.17.008
布加综合征患者腔房转流术后血清MAPK相关蛋白的表达及意义
Expressions of serum MAPK-related proteins in patients with Budd-Chiari syndrome after artificial vascular bypass operation and their clinical significance
摘要
Abstract
Objective To observe the expressions of related proteins of serum mitogen activated protein kinase (MAPK) in patients with Budd-Chiari syndrome (BCS) after artificial vascular bypass operation and discuss their clinical significance. Methods In this study, 40 BCS patients (observation group) and 40 healthy volunteers (control group) were collected. The raleted proteins of serum MAPK were tested by Western blot before operation, 3 days and 1 month after operation, and compared between the two groups. Results The expression levels of serum extracellular signal-regulated kinases 1/2 (ERK1/2), P38, JNK and ERK5 in the observation group before operation, 3 days and 1 month after operation were not significantly different from those in the control group (P >0.05). In the observation group the expression levels of ERK1/2, P38, JNK and ERK5 before operation were not significantly different from those 3 days or 1 month after operation. Compared to the control group, the expression levels of serum P-ERK1/2, P-P38 and P-JNK were higher, while P-ERK5 was lower in the observation group at each time point (P <0.05). In the observation group, the expression levels of serum P-ERK1/2, P-P38 and P-JNK rised, but the P-ERK5 level reduced 3 days after operation compared to the preoperative levels. Conclusions Artificial vascular bypass operation can increase the expression levels of serum P-ERK1/2, P-P38 and P-JNK, but reduce serum P-ERK5 expression.However, it has no obvious regulatory effect on the total protein expressions.关键词
腔房转流术/布加综合征/MAPK/临床研究Key words
artificial vascular bypass operation/Budd-Chiari syndrome/mitogen activated protein kinase/clinical research分类
医药卫生引用本文复制引用
张晓,薛焕洲,王亚东,余淼,黄今朝..布加综合征患者腔房转流术后血清MAPK相关蛋白的表达及意义[J].中国现代医学杂志,2017,27(17):40-44,5.基金项目
河南省医学科技攻关计划重点攻关项目(No:200902006) （No:200902006）
