中国现代医学杂志2017，Vol.27Issue(17)：45-49,5.DOI:10.3969/j.issn.1005-8982.2017.17.009
CCNB2过表达对非小细胞肺癌不良预后的预测效果研究
Cyclin B2 overexpression is a poor prognostic biomarker in NSCLC patients
摘要
Abstract
Objective To identify the role of cyclin B2 (CCNB2) in patients with NSCLC. Methods CCNB2 mRNA and protein expressions were detected in NSCLC and paracancerous tissues. Immunohistochemistry was used to detect the expression of CCNB2 protein in 186 NSCLC patients. The relationships between the expression of CCNB2 and clinicopathological features were analyzed. Results In this study, the expressions of CCNB2 mRNA and protein in the tumor tissues were higher than those in the non-tumor tissues (P<0.05). The expression levels of CCNB2 mRNA and protein were positively correlated with tumor differentiation grade, tumor diameter, lymph node metastasis, distant metastasis and clinical stage (P<0.05), while CCNB2 overexpression was a risk factor for low survival rate and poor prognosis of the patients. Conclusions The overexpression of CCNB2 in NSCLC is closely related to disease progression and poor prognosis, and CCNB2 could be severed as a marker of prognosis in patients with NSCLC.关键词
非小细胞肺癌/细胞周期蛋白B2/生物标志物/预后Key words
CCNB2/NSCLC/biomarker/prognosis分类
医药卫生引用本文复制引用
王杰,陈大兴,郭宁,陶立轩..CCNB2过表达对非小细胞肺癌不良预后的预测效果研究[J].中国现代医学杂志,2017,27(17):45-49,5.基金项目
湖北省武汉市科技基金(No:WX12D26) （No:WX12D26）
