中国现代医学杂志2017，Vol.27Issue(17)：50-53,4.DOI:10.3969/j.issn.1005-8982.2017.17.010
RAGE和sRAGE在胃癌中的表达及其临床意义
Clinical significance of RAGE and sRAGE expressions in gastric cancer
摘要
Abstract
Objective To reveal the clinical significance of the expressions of receptor of advanced glycation end product (RAGE) and soluble RAGE (sRAGE) in gastric cancer and their correlations with tumor differentiation. Methods To study the expression of RAGE in gastric carcinoma tissues, the paraffin-embedded cancerous tissues of 38 patients with stage Ⅰ- Ⅲ gastric cancer without diabetes mellitus were enrolled in this study and 10 samples of adjacent tissues (distance from the edge of the cancer tissues ≥5 cm) as control group. RAGE was analyzed by immunohistochemical staining. To detect the concentration of serum sRAGE, peripheral blood of the 38 gastric cancer patients was collected about 24 hours before operation and on the 7th day after surgery, and the peripheral blood of 30 healthy donors was collected as control group. The concentration of serum sRAGE was analyzed by enzyme-linked immunosorbent assay. Results RAGE was expressed in the adjacent tissues and the gastric tumor tissues, but higher in the gastric tumor tissues (P<0.05). RAGE was not correlated with TNM stage or pathological type of the cancer (P>0.05). The expression levels of preoperative and postoperative serum sRAGE from the 38 patients with gastric cancer were higher than that from the healthy donors (P<0.05). The sRAGE expression level decreased after radical gastrectomy (P<0.05). After the surgery, compared with the patients with stage Ⅱ or Ⅲ gastric cancer, the patients with stage Ⅰ gastric cancer had a lower expression level of serum sRAGE (P< 0.05). Conclusions RAGE expression is up-regulated in gastric tumor tissues, and is helpful to histopathological diagnosis. Serum sRAGE concentration increases in the patients with stage Ⅰ- Ⅲ gastric cancer, which expresses a certain clinical significance in preoperative tumor screening.关键词
胃癌/晚期糖基化终末产物受体/可溶性晚期糖基化终末产物受体Key words
gastric cancer/RAGE/sRAGE分类
医药卫生引用本文复制引用
王嵬,胡炜,苑红,苑春慧..RAGE和sRAGE在胃癌中的表达及其临床意义[J].中国现代医学杂志,2017,27(17):50-53,4.基金项目
辽宁省锦州市科学技术计划(No:12A1B36) （No:12A1B36）
