中国现代医学杂志2017，Vol.27Issue(17)：58-61,4.DOI:10.3969/j.issn.1005-8982.2017.17.012
重症肺炎患者血清NT-proBNP和HMGB1水平的变化及其意义
Changes of serum levels of NT-proBNP and HMGB1 in patients with severe pneumonia and their significance
摘要
Abstract
Objective To investigate the changes of serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high mobility group box 1 protein (HMGB1) in the patients with severe pneumonia and their significance in prediction of prognosis. Methods Totally 96 patients with severe pneumonia were divided into survival group (59 cases) and death group (37 cases). In the same period, 40 healthy subjects were selected as control group. The serum levels of NT-proBNP and HMGB1 were measured and the APACHE Ⅱ scores were recorded for all severe pneumonia patients on day 1, 3, 5 and 7 after admission, and in the control group on the examination day. Results The serum levels of NT-proBNP and HMGB1 on day 1 in the patients with severe pneumonia were higher than those in the control group (P<0.05). Compared with the values on day 1, the serum levels of NT-proBNP and HMGB1 and the APACHE Ⅱ scores in the survival group decreased on day 3, 5 and 7; the serum levels of NT-proBNP and HMGB1 in the death group decreased on day 3 but increased on day 5 and 7, the APACHE Ⅱ scores in the death group increased on day 3, 5 and 7 (P<0.05). The serum levels of NT-proBNP and HMGB1 and APACHE Ⅱ scores on day 1, 3, 5 and 7 in the survival group were lower than those in the death group (P<0.05). Pearson correlation analysis showed that the serum levels of NT-proBNP and HMGB1 in the patients with severe pneumonia were positively correlated with APACHE Ⅱ scores (P<0.05). Conclusions The serum levels of NT-proBNP and HMGB1 in the patients with severe pneumonia increase, and are correlated with the severity and prognosis of the patients. They could be used as adjuvant indicators for assessment of disease and prognosis.关键词
重症肺炎/N末端脑钠肽前体/高迁移率族蛋白B1/预后Key words
severe pneumonia/N-terminal pro-brain natriuretic peptide/high mobility group box 1 protein/prognosis分类
医药卫生引用本文复制引用
刘道莹,刘笛,尹昆..重症肺炎患者血清NT-proBNP和HMGB1水平的变化及其意义[J].中国现代医学杂志,2017,27(17):58-61,4.基金项目
国家自然科学基金(No:31300617) （No:31300617）
