摘要
Abstract
Objective To evaluate the preventive effect of Dezocine on emergence agitation in children af ter cleft lip and palate repair under combined anesthesia with Sevoflurane. Methods Sixty children who underwent cleft lip and palate repair were randomly divided into study group and control group with 30 cases in each group. At the 15th min before the end of the operation, the children in the study group were intravenously injected with Dezocine 0.10 mg/kg, the control group was injected with the same volume of saline. Operation time, extubation time, modified Aldrete score when entering into the Post-anesthesia Care Unit (PACU) and PACU retention time were recorded. At the same time, Pediatric Anesthesia Emergence Delirium (PAED) score, Modified Children's Hospital of Eastern Ontario Pain Scale (m-CHEOPS) score, the incidence of emergence agitation and side effects within 6 h after operation were recorded. Vital signs of all children during intubation (T0), extubation (T1), and 5 min after extubation (T2) were also recorded. Results There was no significant difference in sex, age, body weight, operation time or Sevoflurane inhalation concentration between the two groups ( P>0.05). The PAED score and the m-CHEOPS score in the study group were significantly lower than those in the control group ( P<0.05). The incidence of emergence agitation was significantly lower in the study group than in the control group (χ2=13.871, P=0.000). There was no significant difference in the extubation time, the modified Aldrete score or PACU retention time between the two groups. The MAP of the study group was significantly lower than that of the control group, and the HR was significantly slower than that of the control group at T1 and T2 ( P<0.05). In the study group, the patients were well tolerated to Dezocine without significant adverse reactions. Conclusions In children with cleft lip and palate repair, intravenous administration of Dezocine before the end of surgery can effectively restrain the onset of emergence agitation after general anesthesia, without prolonging awakening and extubation time or obvious adverse reactions.关键词
唇腭裂修复术/地佐辛/全身麻醉/苏醒期躁动Key words
cleft lip and palate repair/Dezocine/general anesthesia/emergence agitation分类
医药卫生
