中国药房2017，Vol.28Issue(22)：3057-3060,4.DOI:10.6039/j.issn.1001-0408.2017.22.09
普乐士泰胶囊对慢性非细菌性前列腺炎模型大鼠的改善作用
Improvement Effect of Prostatitis Capsule on Chronic Non-bacterial Prostatitis Model Rats
摘要
Abstract
OBJECTIVE:To investigate the improvement effect of Prostatitis capsule on chronic non-bacterial prostatitis(CNP) model rats. METHODS:60 rats were randomly divided into sham operation group (distilled water),model group (distilled wa-ter),Pule'an tablet group(positive control,2 g/kg)and Prostatitis capsule high-dose,medium-dose,low-dose groups(16,8,4 g/kg). Except for sham operation group,other 5 groups were injected Xiaozhiling injection 0.2 mL to reduce CNP model. After 7 d of modeling,they received related medicines,ig,once a day,for 45 d. After 24 h of last administration,prostate lesions were ob-served by eyes and wet quality was weighed. White blood cell(WBC)count and lecithin body(SPL)count were conducted under microscope,and prostate tissue slices were pathologically observed. RESULTS:Compared with sham operation group,prostate showed gray nodules,adhesion in glands and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly increased(P<0.01);under microscope,there were significant congestion,edema and a variety of inflammatory cell infiltration in prostate interstitial. Compared with model group,gray nodules in prostate in Pule'an tablet group and Prostatitis capsule group were reduced,as well as adhesion degree in prostate and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly decreased(P<0.01);pathological changes had improved to varying degrees under micro-scope,especially the changes in Prostatitis capsule high-dose group,and prostate tissue only showed mild congestion,edema and little inflammatory cell infiltration. CONCLUSIONS:Prostatitis capsule has a certain improvement effect on CNP model rats.关键词
普乐士泰胶囊/慢性非细菌性前列腺炎/白细胞/卵磷脂小体/大鼠Key words
Prostatitis capsule/Chronic non-bacterial prostatitis/Leukocytes/Lecithin body/Rats分类
医药卫生引用本文复制引用
叶绿萍,李德钢,刘素春,马儒清,宾彬..普乐士泰胶囊对慢性非细菌性前列腺炎模型大鼠的改善作用[J].中国药房,2017,28(22):3057-3060,4.基金项目
广西壮族自治区卫生厅中医药科技专项课题/广西壮族自治区卫生厅医院制剂遴选课题(No.GZYZ1105) （No.GZYZ1105）
