中国药房2017，Vol.28Issue(22)：3121-3124,4.DOI:10.6039/j.issn.1001-0408.2017.22.26
多指标综合评分正交试验法优化熟地黄的炮制工艺
Optimization of the Processing Technology of Rehmanniae Radix Praeparata by Muti-indexes Integrating Score-Orthogonal Test
摘要
Abstract
OBJECTIVE:To optimize the processing technology of rehmanniae radix praeparata. METHODS:Using transfer rates of catalpol,rehmaionoside D,acteoside,isoacteoside,polysaccharide as indexes for comprehensive score,heating tempera-ture(pressure),heating time and heating times as investigating factors,L9(34)orthogonal test was used to optimize the processing technology of rehmanniae radix praeparata,and verification test was conducted. RESULTS:The optimal processing technology of rehmanniae radix praeparata was as follow as heating temperature of 125 ℃,pressure of 150 kPa for twice,2 h every time. The comprehensive scores of 3 batches of samples were 0.6985,0.6755,0.7016 in the verification test,respectively,RSDs were less than 5%(n=3). CONCLUSIONS:Optimized processing technology is simple,stable,feasible,and can provide reference for in-dustrial production of rehmanniae radix praeparata.关键词
熟地黄/正交试验/炮制工艺/多指标/综合评分Key words
Rehmanniae radix praeparata/Orthogonal test/Processing technology/Muti-indexes/Comprehensive score分类
医药卫生引用本文复制引用
屠万倩,周志敏,张留记,刘晓苗,张宝,崔伟峰,李开言,周丽..多指标综合评分正交试验法优化熟地黄的炮制工艺[J].中国药房,2017,28(22):3121-3124,4.基金项目
国家中医药管理局重点研究室建设项目(No.0907291) （No.0907291）
河南省重点科技攻关计划项目(No.102102310018) （No.102102310018）
