中山大学学报（医学科学版）2017，Vol.38Issue(4)：494-497,544,5.
P-选择素敲除对自发肠道腺瘤ApcMin/+小鼠中晚期肿瘤生长的作用
Effect of P-selectin Deletion on Intestinal Tumorigenesis in 15,24-week-old ApcMin/+ Mice
摘要
Abstract
[Objective] To investigate the effect of P-selectin on the intestinal tumorigenesis in the 15,24-week-old ApcMin/+ mice.[Methods] Male ApcMin/+ mice were mated with female P-selectin knockout (P-sel-/-) mice to generate AMin/+Ps-/-mice.The diameters and numbers of the intestinal tumors in the intestines of ApcMin/+ and AM/+ps-/-mice were measured using an inverted microscope.The tumor volumes were measured using the following equation:volume =0.52 × (length × width2).[Results] There were no significant difference between the volume and number of intestinal tumor in 15-week-old ApcMin/+ mice and 15-week-old A+ P-mice.The volume and number of intestinal tumor were significantly increased in 24-week-old A+P-mice compared to 24-weekold ApcMin/+ mice.P-selectin deletion significantly prolonged the survival time of ApcMin/+ mice.[Conclusions] P-selectin deletion promotes the intestinal tumorigenesis in the 24-week-old ApcMin/+ mice.关键词
P-选择素/肠道肿瘤/基因工程小鼠Key words
P-selectin/intestinal tumor/genetically engineered mice分类
医药卫生引用本文复制引用
何亚军,曹静桦,李梦诗,郭四美,王丽京,亓翠玲..P-选择素敲除对自发肠道腺瘤ApcMin/+小鼠中晚期肿瘤生长的作用[J].中山大学学报（医学科学版）,2017,38(4):494-497,544,5.基金项目
国家自然科学基金青年项目(31500966) （31500966）
广东省科技计划项目(2013B021800082,2015A020211029,2014A020212314) （2013B021800082,2015A020211029,2014A020212314）
广州市科技计划项目(201607010135) （201607010135）
