重庆医学2017，Vol.46Issue(22)：3050-3052,3056,4.DOI:10.3969/j.issn.1671-8348.2017.22.008
前列腺影像报告与数据系统对前列腺特异性抗原灰区前列腺癌的诊断价值
Diagnostic value of prostate image report and data system (PIRADS version 2) in prostate cancer with grey zone of prostate specific antigen
摘要
Abstract
Objective To access the diagnostic value of Prostate Imaging Reporting and Data System (PIRADS version 2)for prostate cancer (PCa) in prostate specific antigen (PSA) grey zone(4-10 ng/mL).Methods Treatment naive PCa and BPH patients with an increase of PSA 4-10 ng/mL from 2200 patients underwent prostate MRI from 2012 to 2016 were included,multiparameter magnetic resonance imaging (mp-MRI) prior biopsy or prostatectomy and clinical data were obtained,mp-MRI were retrospectively analyzed quantitatively by a radiology expert with 15 years experience in urogenital system imaging diagnosis and a doctor with 5 years experience in radiology diagnosis blind to the pathology results according to PIRADS v2,PIRADS v2 score and lesion zone were recorded respectively,in case of disagreement,dicision was made through discuss.TRUS guided biopsy or prostatectomy pathology serves as gold reference.Diagnostic value of PIRADS v2 for PSA grey zone PCa was calculated by receiver operating characteristic (ROC) curve,logistic regression analysis was used to access the risk factors of PCa.Results 15 PCa and 30 BPH patients were in eluded.There was no significant difference between these two groups in age,tPSA,fPSA,f/tPSA,prostate volume and PSA density.The area under ROC curve of PIRADS v2 in diagnosing PCa was 0.932[95 ％ CI 0.822-0.984],P＜0.01.Using a cutoff PIRADS＞4,the diagnosis sensitivity was 88.89 ％,specificity 87.10 ％,and positive predictive value 80 ％,negative predictive value 93.10％,respectively.Logistic regression analysis showed that PIRADS v2 score was an independent risk factor for predicting PCa,with a hazard ratio 17.847[3.745-85.078],P＜0.01.There was a positive correlation between PIRADS v2score and gleason score,r=0.585,P=0.022.Conclusion PIRADS v2 has a significantly high diagnosis value in diagnosing PSA grey zone PCa and a good correlation with pathology results.关键词
前列腺增生/前列腺肿瘤/前列腺特异抗原/前列腺影像报告与数据系统Key words
prostatic hyperplasia/prostatic neoplasms/prostate specific antigen/prostate imaging reporting and data system分类
医药卫生引用本文复制引用
康振,张配配,李拔森,闵祥德,冯朝燕,可赞,王良..前列腺影像报告与数据系统对前列腺特异性抗原灰区前列腺癌的诊断价值[J].重庆医学,2017,46(22):3050-3052,3056,4.基金项目
国家自然科学基金资助项目(8167070843). （8167070843）
