重庆医学2017，Vol.46Issue(22)：3073-3076,4.DOI:10.3969/j.issn.1671-8348.2017.22.015
4种血清肿瘤标志物及粪便隐血的联合检测在Dukes B期结肠癌诊断中的应用
Application of combined detection of serum CEA,CA199 ,CA125,AFP and fecal occult blood in diagnosis of Dukes B stage colon carcinoma
摘要
Abstract
Objective To study the diagnostic value of combined detection of serum CEA,CA199,CA125,AFP and fecal occult blood(FOB) in Dukes B stage colon carcinoma.Methods The above indicators in 56 patients with colon carcinoma (colon carcinoma group),35 patients with colonic polyp benign disease and 41 healthy individuals undergoing physical examination were measured.Then the sensitivity,and specificity of single index detection and their combined detection were analyzed.Results The levels and positive rates of CEA,CA199,CA125 and FOB in the colon cancer group were significantly higher than those in the colonic polyp group and healthy control group (P＜0.05),but the AFP level and positive rate had no statistical difference compared with the colonic polyp group.Serum CEA,CA125,CA199 and FOB were selected into the Logistic regression equation.The corresponding areas under the curve (AUC) were 0.745,0.886,0.792 and 0.864 respectively;the positive detection rates were 48.2 ％,35.7 ％,39.3 ％ and 78.6 ％ respectively.The combined detection could increased the specificity,sensitivity and AUC to 87.5 ％,92.1％ and 0.957,which were more superior to that in the single index detection.Conclusion The combined detection of serum CEA,CA199,CA 125 and FOB can provide the powerful basis for early diagnosing colonic cancer.关键词
结肠肿瘤/Logistic模型/癌胚抗原/甲胎蛋白类/受试者特征曲线/粪便隐血Key words
colonic neoplasms/Logistic model/carcinoembryonic antigen/alpha-fetoproteins/receiver operative characteristic curve/fecal occult blood分类
医药卫生引用本文复制引用
汤军,欧俐苹,陈玲,翁亚光,徐增伟,张明昊..4种血清肿瘤标志物及粪便隐血的联合检测在Dukes B期结肠癌诊断中的应用[J].重庆医学,2017,46(22):3073-3076,4.基金项目
重庆市科学技术委员会社会事业与民生保障科技创新专项(cstc2015shmszx120069) （cstc2015shmszx120069）
重庆市卫生经济学会重点项目(YWJK2017-1) （YWJK2017-1）
重庆市沙坪坝区科学技术委员会科技项目(KP201513,KP201610) （KP201513,KP201610）
重庆医科大学创新实验基金项目(2015-56). （2015-56）
