重庆医学2017，Vol.46Issue(22)：3080-3082,3.DOI:10.3969/j.issn.1671-8348.2017.22.017
预防性应用抗抑郁药物对急性脑梗死预后及血清BDNF水平的影响
Effects of preventive antidepressant application on prognosis and serum BDNF level of acute cerebral infarction
摘要
Abstract
Objective To investigate the effect of preventive antidepressants application on the prognosis of and serum brain derived neurotrophic factor(BDNF) level in acute cerebral infarction(ACI).Methods One hundred and forty-one patients with ACI were prospectively and randomly selected.Seventy-two cases in the intervention group was added with sertraline for 12 weeks on the basis of the routine therapy,while 69 cases in the control group only used the routine therapy.The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the nervous function impairment degree and daily living ability.The Hamilton Depression Rating Scale-17 was used to evaluate the emotion after stroke.The cognition function was evaluated by the Mini-Mental State Examination (MMSE).The BDNF level was detected by using the double antibody sandwich enzyme-linked immunosorbent assay.Results The NIHSS and HAMD scores after 3-month treatment were (1.77±0.58)points and (5.43±1.77)points in the intervention group,and (4.06±0.79)points and(10.27±3.78)points in the control group,which were significantly decreased compared with before treatment(P＜0.05);the BI value in the intervention group and control group were (96.24±4.58) and (77.64±6.96),which weresignificantly increased compared with before treatment (P＜0.05),and serum BDNF levels were (8.38±0.74)ng/mL and (5.72 ±0.67)ng/mL respectively,which were significantly increased compared with before treatment,moreover the change in the intervention group was more obvious than that in the control group (P＜0.05).The MMSE score had no statistical difference between the two groups (P＞0.05).The PSD occurrence rate was 10.0％ in the intervention group,which was significantly decreased compared with 53.6％ in the control group (P＜0.05).Conclusion Preventive antidepressants application in the patients with ACI can increase the serum BDNF level,improves the prognosis and is worth promotion and application.关键词
脑梗死/抗抑郁药/预后/脑源性神经营养因子Key words
cerebral infarction/antidepressive agents/prognosis/BDNF分类
医药卫生引用本文复制引用
曹金霞,姜建东,刘莉,孙云涛,曾庆宏,王金芳..预防性应用抗抑郁药物对急性脑梗死预后及血清BDNF水平的影响[J].重庆医学,2017,46(22):3080-3082,3.基金项目
江苏大学医学临床科技发展项目(JLY20140131). （JLY20140131）
