摘要
Abstract
Objective To study the clinical effect of different rescue treatments on steroid-resistant severe ulcerative colitis (UC).Methods 60 patients with steroid-resistant severe UC were randomly assigned to two groups,with 30 cases in each group.The treatment group was treated with infliximab (IFX) and the control group with cyclosporin A (CsA).The platelet,C-reactive protein (CRP),hemoglobin (HGB),albumin (Alb) and erythrocyte sedimentation rate (ESR) before and after treatment,the treatment effect and adverse drug reactions were compared between the two groups.Results The clinical efficacy of the treatment group was significantly better than that of the control group (P ＜ 0.05).The platelet count,CRP,HGB,Alb and ESR of the observation group at 3 months and at the end of treatment were significantly different with the control group and before treatment (P ＜ 0.05).There were no significant difference between the two groups in transfusion reaction,virus infection,gastrointestinal reaction and transaminase elevation (P ＞ 0.05).Conclusion IFX is more effective than CsA in steroid resistant severe UC,and can effectively improve intestinal inflammatory symptoms with high safety.关键词
溃疡性结肠炎/激素抵抗/英夫利昔/环孢素AKey words
ulcerative colitis/glucocorticoid resistance/Infliximab/Cyclosporin A分类
医药卫生
