分析测试学报2017，Vol.36Issue(6)：768-772,5.DOI:10.3969/j.issn.1004-4957.2017.06.011
超高效液相色谱-串联四极杆质谱法测定麻辣烫中喹诺酮类药物残留
Determination of Quinolones in Hotpot Using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry
摘要
Abstract
An ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was established for the determination of 14 quinolones in hotpot.Samples were extracted with acidified acetonitrile,defated with n-hexane,separated on a C1s solid phase extraction(SPE)column,and analyzed by LC-ESI-MS/MS under the positive mode with multiple reaction monitoring(MRM).The method showed good linearities for 14 quinolones over the range of 7.5-100 μg/L with correlation coefficients(r) more than 0.990.The detection limits of 14 quinolones were 0.5 μg/kg,and the quantitation limits were 1.5 μg/kg.The recoveries of all analytes in hotpot ranged from 75.4％ to 110.0％ with relative standard deviations (RSD,n =6) of 1.3％-10.1％.The method has the advantages of simplicity,rapidness,good purifying effect and sensitivity,and is suitable for the simultaneous determination of quinolones in hotpot.关键词
固相萃取/超高效液相色谱-串联四极杆质谱法/喹诺酮类药物/麻辣烫Key words
SPE/ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)/quinolones/hotpot分类
化学化工引用本文复制引用
赵飞,高广慧,贾宏新..超高效液相色谱-串联四极杆质谱法测定麻辣烫中喹诺酮类药物残留[J].分析测试学报,2017,36(6):768-772,5.基金项目
国家质检总局科研计划项目(2016IK169) （2016IK169）
