影像科学与光化学2017，Vol.35Issue(4)：546-551,6.DOI:10.7517/j.issn.1674-0475.2017.04.016
基于新型不对称BODIPY的GSH荧光探针
A BODIPY-based Fluorescent Probe for Selective Detection of GSH
摘要
Abstract
Here,a BODIPY-based dye was constructed by appending malononitrile,an electron acceptor,to the BODIPY core via a vinylene bridge.The designed BODIPY proceeded aromatic nucleophilic substitution (SNAr) toward sulfhydryl-containing nucleophiles in buffer systems.Experimental data demonstrated that the reactions between CN-B-Cl and thiol-containing amino acids (GSH,Cys/Hcy) produced different BODIPYs with distinct fluorescent signals,thus allowing CN-B-Cl for discriminating GSH from Cys/Hcy.关键词
BODIPY/芳香亲核取代/荧光探针/GSHKey words
BODIPY/aromatic nucleophilic substitution/fluorescent probe/GSH引用本文复制引用
费强,安建才,赵春常..基于新型不对称BODIPY的GSH荧光探针[J].影像科学与光化学,2017,35(4):546-551,6.基金项目
国家自然科学基金项目(21372083,21672062)资助 （21372083,21672062）
