影像科学与光化学2017，Vol.35Issue(4)：574-580,7.DOI:10.7517/j.issn.1674-0475.2017.04.019
紫外光共聚交联制备GelMA/PEGDA水凝胶
Synthesis of GelMA/PEGDA Hydrogel by UV Photopolymerization
王毅虎 1张兵 2马铭 1卢伟鹏 1王佳宁 1郭燕川1
作者信息
- 1. 中国科学院理化技术研究所化学转化与功能材料重点实验室,北京100190
- 2. 中国科学院大学,北京100049
- 折叠
摘要
Abstract
To avoid the thermolability of physically cross-linked gelatin hydrogel and toxicity of chemically crosslinked gelatin hydrogel,double bonds were introduced to gelatin molecule chain by acrylation,and then gelatin methacrylamide(GelMA) and polyethylence glycol diacrylate(PEGDA) were cross-linked to hydrogels by the UV photopolymerization.The relationship between the quantity of methacrylic anhydride(MA) and degree of modification and physicochemical properties of GelMA/PEGDA were investigated and analyzed.The result indicated that more radicals could be released in the system when more PEGDA were added.So the activity and extent of crosslinking reaction was increased and hydrogel with much denser 3D network was formed.Crosslinked GelMA/PEGDA hydrogel have better thermal stability than cross linked GelMA at 37 ℃.Cross-linked GelMA/PEGDA hydrogel can be used as scaffold materials of tissue engineering.关键词
水凝胶/紫外光聚合/甲基丙烯酰胺基明胶/聚乙二醇双丙烯酸酯Key words
hydrogel/UV photopolymerization/gelatin methacrylamide/polyethylence glycol diacrylate引用本文复制引用
王毅虎,张兵,马铭,卢伟鹏,王佳宁,郭燕川..紫外光共聚交联制备GelMA/PEGDA水凝胶[J].影像科学与光化学,2017,35(4):574-580,7.
