国际妇产科学杂志2017，Vol.44Issue(4)：406-411,6.
蜕膜自然杀伤细胞在妊娠并发症中的作用研究进展
Research Progress on the Role of Decidual Natural Killer Cells in Pregnancy Complications
摘要
Abstract
Decidual natural killer (dNK) cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. However, the mechanisms of dNK cells during pregnancy are mostly unknown. By secreting cytokines/chemokines and angiogenic factors, dNK cells participate in normal placentation including feto-maternal tolerance, spiral artery remodeling and neovascularization during decidualization in a successful pregnancy. In recent years, dNK cells have been found to be closely related to the occurrence and maintenance of normal pregnancy. It has also been found that abnormal changes of DNK cell cytology and immunology and other aspects are common in complications of pregnancy such as recurrent spontaneous abortion, pre-eclampsia, etc. This review intended to summarize and discuss recent data that may challenge the conventional view of dNK cells, including quantitative, phenotypic, secretory cytokines and angiogenic factors, and possible mechanisms of dNK cells in the pathogenesis of pregnancy complications. To elucidate latest knowledge on dNK cells, may guide the prevention and treatment of complicated pregnancies.关键词
杀伤细胞,天然/蜕膜/流产,习惯性/先兆子痫Key words
Killer cells/natural/Decidua/Abortion/habitual/Pre-eclampsia引用本文复制引用
廖娥,邵勇..蜕膜自然杀伤细胞在妊娠并发症中的作用研究进展[J].国际妇产科学杂志,2017,44(4):406-411,6.基金项目
国家自然科学基金(81471473),重庆市卫计委医学高端后备人才培养项目(2015XMSB0001298) （81471473）
