国际妇产科学杂志2017，Vol.44Issue(4)：450-454,5.
线粒体功能障碍与卵巢衰老
Mitochondrion Dysfunction and Ovarian Aging
摘要
Abstract
Mitochondria are centers for cellular energy supply. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular. Mitochondria are one of the most important organelles in oocytes, which play a key role in early embryo development. Dysfunctional mitochondria is discussed as major factor in predisposition to chromosomal nondisjunction during meiotic division and mitotic errors in embryos, and in reduced quality and developmental potential of aged oocytes and embryos. Oocytes quality reduction is associated with abnormal spindle, chromosome alignment, telomere shortening and absence of fibronectin in meiosis, which could result in aneuploid oocytes and infertility. Mitochondrial DNA (mtDNA) copy number is a potential biomarker of oocytes quality and embryo viability. The usage of mitochondrial nutrients and autologous mitochondrial transfer will be a potential treatment for poor ovarian function and response.关键词
线粒体/卵母细胞/DNA,线粒体/胚胎发育/生殖技术,辅助Key words
Mitochondria/Oocytes/DNA/mitochondrial/Embryonic development/Reproductive techniques/assisted引用本文复制引用
侯海燕,郁琦..线粒体功能障碍与卵巢衰老[J].国际妇产科学杂志,2017,44(4):450-454,5.基金项目
国家自然科学基金(81402691) （81402691）
天津市应用基础与前沿技术研究计划(15JCQNJC12300) （15JCQNJC12300）
