国际妇产科学杂志2017，Vol.44Issue(4)：455-458,4.
内皮祖细胞在子宫内膜异位症血管形成中的研究进展
The Role of Endothelial Progenitor Cells in the Vasculogenesis of Endometriosis
摘要
Abstract
Endometriosis is a complex disease with a multifactorial pathogenesis, which is crucially dependent on the neovascularization. The present review highlights the fact that the neovascularization of endometriotic lesions is not only driven by angiogenesis, but also involves de novo formation of microvessels from circulating endothelial progenitor cells (EPC). This process, termed vasculogenesis, is a characteristic of various pathogenic conditions, such as tumour growth and atherosclerosis, and typically comprises the activation, mobilization and recruitment of bone marrow-derived EPC to the sites of tissue hypoxia. Recent studies indicate that part of the microvascular endothelium of ectopic endometrial tissue originates from EPC, and controlled by the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor type 4 (CXCR4) axis. Accordingly, blockade of EPC recruitment effectively inhibits the formation of microvascular networks in developing endometriotic lesions, indicating that vasculogenesis represents an integral part of the pathogenesis of endometriosis. The involvement of vasculogenesis in endometriosis may offer the exciting opportunity for the future establishment of novel diagnostic and therapeutic strategies for this frequent gynecological disease.关键词
子宫内膜异位症/干细胞/新生血管化,病理性Key words
Endometriosis/Stem cells/Neovascularization/pathologic引用本文复制引用
李林翰,钱欢欢,朱姝,徐炜,王秀丽..内皮祖细胞在子宫内膜异位症血管形成中的研究进展[J].国际妇产科学杂志,2017,44(4):455-458,4.基金项目
2016年江苏省高层次卫生人才"六个一工程"项目(LGY2016003) （LGY2016003）
