摘要
Abstract
Objective To investigate whether deficient 25-hydroxy vitamin D (25-OHD) levels of very low birth weight preterm infants at birth and mothers are important high risk factors of bronchopulmonary dysplasia (BPD) in very low birth weight preterm infants.Methods Preterm infants no more than 1500g of birth weight with respiratory distress syndrome (RDS) who were admitted in Zhengzhou Children Hospital during March 2014 and June 2015 were enrolled.Levels of 25-OHD of infants were obtained at admission (within 3 days after birth) to neonatal intensive care unit (NICU) and of mothers were determined.Infants were divided into BPD group and no-BPD group according to whether complicating BPD after 28 days.Results Among 80 infants, 24 cases (30.00%) developed BPD, 50 cases did not, and 6 cases died or discharged privately.Mechanical ventilation time, continuous positive airway pressure (CPAP), total oxygen use time, hospitalization length and number of patent ductus arterious (PDA) cases were significantly higher in BPD group than in non-BPD group (t value was 9.047, 6.275, 11.395 and 15.398, respectively, χ2=4.010, all P<0.05).Both maternal and neonatal 25-OHD levels in BPD group were signicantly lower than those in no-BPD group (t value was 7.003 and 9.082, respectively, both P<0.05).All of the infants in BPD group had a 25-OHD level lower than 10ng/mL, which indicated serious lack.Logistic regression analysis revealed that 25-OHD level at birth was the high risk factor of BPD.The incidence of BPD was de-creased by 24% (OR:0.76, 95%CI: 68-86, P<0.001) and 39% (OR:0.61, 95%CI: 48-76,P<0.001) for every 1ng/mL increase of 25-OHD in mother and neonatal serum.Conclusion The study shows that lower maternal and neonatal vitamin 25-OHD levels are high risk factors of BPD development in very low birth weight preterm infants.However, further studies are needed to delineate whether supplement of vitamin D to preterm infants at early stage can prevent BPD and other diseases.关键词
极低出生体重儿/新生儿支气管肺发育不良/维生素D/25-羟基维生素DKey words
very low birth weight infant (VLBWI)/bronchopulmonary dysplasia (BPD)/vitamin D/25-hydroxy vitamin D (25-OHD)分类
医药卫生
