中国妇幼健康研究2017，Vol.28Issue(8)：998-1000,3.DOI:10.3969/j.issn.1673-5293.2017.08.037
靶向卵巢癌糖酵解途径治疗的研究进展
Progress in targeting glycolysis pathway in ovarian cancer
摘要
Abstract
Previous studies have shown that even under the conditions of sufficient oxygen, tumor metabolism is still more inclined to glycolysis, which is known as Warburg effect.Ovarian cancer is the leading cause of death of gynecologic malignancies.The key enzymes of glycolysis (HK, PFK, PKM) are overexpressed in a variety of tumors, including ovarian cancer, and the transformation of tumor's glycolysis can improve the resistance of chemotherapy drugs and thus inhibit tumor proliferation.In this paper, the biological characteristics of these key enzymes in the glycolysis pathway and the progress on targeting these glycolysis enzymes in ovarian cancer therapy were summarized.关键词
卵巢癌/Warburg效应/糖酵解途径关键酶/治疗进展Key words
ovarian cancer/Warburg effect/key enzymes of glycolysis pathway/progress in therapy分类
医药卫生引用本文复制引用
张萌,李桂玲,彭靖,张晓燕,徐丛剑..靶向卵巢癌糖酵解途径治疗的研究进展[J].中国妇幼健康研究,2017,28(8):998-1000,3.基金项目
国家自然科学基金资助项目(81472424) （81472424）
