摘要
Abstract
Objective To evaluate the efficacy and safty of misoprostol combined with COOK balloon in labor induction of term pregnancy.Methods From January 2013 to August 2016 altogether 257 primiparas in full term with indication for induced labor, cervical score equal to or greater than 6 and no contraindication were selected from Chengdu Fifth People's Hospital and Chengdu Second People's Hospital and randomly divided into four groups, misoprostol and COOK balloon group, misoprostol group, oxytocin group, and oxytocin and COOK balloon group.Bishop score of cervix before and after cervical ripening, rates of vaginal delivery and cesarean delivery, time from contractions to labor, duration of each stage, blood loss in vaginal delivery, postpartum hemorrhage rate, assisted vaginal delivery rate, cervical and vaginal laceration incidence, as well as neonatal 1 min Apgar score were compared among four groups.Results Cervical Bishop score had no significant difference before using COOK balloon or misoprostol among COOK group, misoprostol group and oxytocin group (F=0.85,P>0.05).After using COOK balloon or misoprostol, cervical Bishop score in COOK balloon group, misoprostol group and oxytocin group had significant difference (F=36.421,P<0.05).COOK balloon was more effective on promoting cervical ripening.There was significant difference in cesarean delivery rate in four groups (χ2 =87.26,P<0.05).Comparison among groups showed that no significant difference in cesarean rate was found between misoprostol group and oxytocin and cook balloon group (χ2 =9.17, P>0.05).Difference in contraction to delivery time among four groups was statistically significant (F=15.71, P<0.05) with COOK balloon and oxytocin group better than other groups (t value was 1.03, 6.61 and 2.78, respectively, all P<0.05).Difference in first stage, total stage of labor and blood loss in vaginal delivery among groups had statistical significance (F value was 44.55, 48.38 and 3.79, respectively, all P<0.05).Difference in second and third stage of labor among groups was not significant (F value was 1.66 and 2.14, respectively, both P>0.05).There was no significant difference in assisted vaginal delivery rate and episiotomy rate among four groups (χ2 value was 1.26 and 3.71, respectively, both P>0.05).Conclusion Application of misoprostol combined with COOK balloon in labor induction of term pregnancy is safe and effective, and can reduce cesarean delivery rate.关键词
米索前列醇/COOK球囊/引产/促宫颈成熟Key words
misoprostol/COOK balloon/labor induction/cervical ripening分类
医药卫生
