临床与病理杂志2017，Vol.37Issue(6)：1111-1116,6.DOI:10.3978/j.issn.2095-6959.2017.06.006
长链非编码RNA uc.299在心脏发育中的作用
Effect of long non-coding RNA uc.299 on heart development
摘要
Abstract
Objective:To investigate the function oflncRNA uc.299 in the heart development of zebra fish and differentiation of P19 cells.Methods:In in vitro experiment,the effect of uc.299 knockdown on P19 cells differenctiation were detected;and in vivo,after macroinjecting the zygotes zebra fish with uc.299 antisense oligonucleotide,the cardic development of the zebra fish was observed.Results:The differentiation and related cardiac biomarkers of P 19 are reduced as well as the heart development of zebrafish post Knockdown of uc.299.Conclusion:The differentiation and development are influenced post knockdown of uc.299.It indicates that uc.299 may play a role in maintaining heart development.关键词
长链非编码RNA/室间隔缺损性先天性心脏病/P19/斑马鱼/作用Key words
long non-coding RNA/ventriculap septal defect/P19/zebra fish/function引用本文复制引用
朱晓静,程子杰,冯梦文,尹安雯,沈丹,王兴,李沄..长链非编码RNA uc.299在心脏发育中的作用[J].临床与病理杂志,2017,37(6):1111-1116,6.基金项目
国家自然科学基金(81601333).This work was supported by the National Natural Science Foundation of China (81601333). （81601333）
