临床与病理杂志2017，Vol.37Issue(6)：1171-1176,6.DOI:10.3978/j.issn.2095-6959.2017.06.016
Bcl-2,Cox-2,HSPs和p53在骨肉瘤患者中的表达及临床意义
Expression and clinical significance of bcl-2, Cox-2, HSPs and p53 in patients with osteosarcoma
摘要
Abstract
Objective:To observe and analyze the difference and clinical significance of the expression of biomarkers such as bcl-2,Cox-2,HSPs and p53 in osteosarcoma tumor tissues,and explore the potential roles that the biomarker might play in the genesis and development of osteosarcoma,in order to provide the theoretical foundation for the pathological diagnosis and treatment of OS.Methods:The achieved wax tissues that with typical morphological of osteosarcoma,and then Streptavidin-Peroxidase (S-P) dyeing for the slice,the patients diagnosed as osteochondroma in the same period were selected as the control group.The expression of the protein molecular biomarker,such as bcl-2,Cox-2,HSPs and p53,were observed,the differences of the proteins expression and its clinical significance between the two groups were analyzed by Chi-square test.Results:The positive expression of bcl-2,Cox-2,HSP70/90,and p53 protein in the osteosarcoma group were significantly higher than that in the osteochondroma group (P＜0.05).The expression of Vim protein had no significant difference between the two groups.Conclusion:Bcl-2,Cox-2,HSPs and Vim play important roles in the formation and progression of osteosarcoma tumor lesions,and provide the theoretical basis for pathological diagnosis and precision medicine.关键词
骨肉瘤/免疫组织化学/生物标志物/p53/热休克蛋白Key words
osteosarcoma/immunohistochemical staining/biomarker/p53/HSPs引用本文复制引用
张浩强,李明辉,鲁亚杰,叶铄,田琦,周胜虎,李旭升,王臻..Bcl-2,Cox-2,HSPs和p53在骨肉瘤患者中的表达及临床意义[J].临床与病理杂志,2017,37(6):1171-1176,6.基金项目
国家自然科学基金(31370944,31170914). This work was supported by National Natural Science Foundation of China (31370944,31170914). （31370944,31170914）
