临床与病理杂志2017，Vol.37Issue(6)：1177-1183,7.DOI:10.3978/j.issn.2095-6959.2017.06.017
信号素4D在结直肠癌组织中的表达及其与微血管密度的关系
Expression of Semaphorin 4D in colorectal carcinoma and its relationship with microvessel density
赵艳红 1王帆荣 1陈芸 1张丽娟1
作者信息
- 1. 昆明医科大学第三附属医院云南省肿瘤医院病理科,昆明650000
- 折叠
摘要
Abstract
Objective:To investigate the expression of semaphorin 4D (Sema4D) in colorectai carcinoma and its correlation with microvessel density (MVD).Methods:We retrospectively analyzed the clinical and pathological data of 61 patients with co]orectal cancer undergoing colorectal surgery from 2014 to 201S in Yunnan Provincial Tumor Hospital.The expression levels of Sema4D protein in colorectal cancer tissues and 56 cases of adjacent tissues were detected by immunohistochemical SP method.MVD markers were used to count microvessels labeled with CD34.Results:Sema4D was mainly expressed in the cytoplasm and cytoplasm of colorectal carcinoma,and the expression of Sema4D was negative in the cytoplasm of the adjacent tissues.The positive rate of Sema4D expression in cancer tissues (61/61) was significantly higher than that in adjacent tissues (0/56),the difference was statistically significant (x2=13.027,P＜0.001).Sema4D and MVD were analyzed by Spearman correlation coefficient (r=0.333,P=0.009),which had significant positive correlation.T test analysis of MVD expression indicated significant differences between the high and low expression of S ema4D groups (P=0.003).Conclusion:Sema4D is highly expressed in colorectal cancer tissue,and there is a significant correlation with MVD,suggesting that it is potential to be a potential therapeutic target ofcolorectal cancer.关键词
信号素4D/结直肠癌/微血管密度Key words
semaphoring 4D/colorectal cancer/microvessel density引用本文复制引用
赵艳红,王帆荣,陈芸,张丽娟..信号素4D在结直肠癌组织中的表达及其与微血管密度的关系[J].临床与病理杂志,2017,37(6):1177-1183,7.
