临床与病理杂志2017，Vol.37Issue(6)：1226-1230,5.DOI:10.3978/j.issn.2095-6959.2017.06.026
胰岛素生长因子受体-2在肝细胞癌预后判断中的临床价值
Clinical value of IGF-2R in prognosis of hepatocellular carcinoma
丁晶晶 1陈洁 2刘欣艳3
作者信息
- 1. 上海市普陀区中心医院老年科,上海200062
- 2. 湖北医药学院附属随州医院肿瘤科,湖北随州44130
- 3. 南通大学医学院肿瘤学,江苏南通226001
- 折叠
摘要
Abstract
Objective:To study the clinical value of insulin-like growth factor-2 receptor (IGF-2R) in the prognosis of hepatocellular carcinoma (HCC).Methods:We examined IGF-2R expression in human HCC tissues by immunohistochemical staining,and investigated the clinical correlation between IGF-2R tissue levels and the clinicopathological characteristics of HCC patients.Results:Immunohistochemistry results revealed that IGF2R was mainly expressed in the cell membrane and plasma of HCC cells.IGF-2R protein levels were significantly higher in HCC tissues when compared with matched non-cancerous tissues,the difference was statistically significant (P＜0.05),and associated with the degree of tumor differentiation (P=0.012).Univariate and multivariate survival analysis revealed that patients with high IGF-2R expression (HR =9.87,95％ CI 4.13-17.80,P=0.008)and advanced TNM stage (HR =5.21,95％ CI 1.38-10.76,P=0.023) and poor prognosis (HR =2.30,95％ CI 1.20-5.01,P=0.033).Conclusion:These data indicate that IGF-2R expression is associated with the overall survival of HCC patients,and may represent a novel molecular target and newprognostic biomarker for HCC.关键词
肝细胞癌/胰岛素生长因子受体-2/预后/存活/分子靶向Key words
hepatocellular carcinoma/insulin-like growth factor-2 receptor/prognosis/survival/molecular target引用本文复制引用
丁晶晶,陈洁,刘欣艳..胰岛素生长因子受体-2在肝细胞癌预后判断中的临床价值[J].临床与病理杂志,2017,37(6):1226-1230,5.
