临床与病理杂志2017，Vol.37Issue(6)：1304-1309,6.DOI:10.3978/j.issn.2095-6959.2017.06.039
微血管损伤对急性心肌梗死患者的影响
Effect of microvascular injury in acute myocardial infarction patients
摘要
Abstract
Despite the epicardial coronary blood flow was successfiully restored of myocardial infarction patients,a significant proportion of patients with myocardial infarction is still suffering from severe microvascular perfusion injury.In addition to aortic dissection,embolism,cramping and stenosis,this reperfusion failure at the microvascular level is a condition known as no-reflow (NR) or microvascular injury.The underlying pathophysiology of microvascular injury is complex and multifactorial and is not fully understood.The presence of myocardial infarction is a serious prognostic sign.Microvascular injury is regarded as independent predictor of death or recurrent myocardial infarction.It is a multi-factorial and individual susceptibility phenomenon and has not yet established a perfect and effective control strategy.For most of the clinical results are not satisfactory,its prevention and treatment strategies to less or avoid the impact of microvascular injury still remain a major challenge so far.This review summarizes the main mechanisms ofpathophysiological pathogenesis and current strategies of prevention and treatment.关键词
心肌梗死/微循环损伤/无复流Key words
myocardial infarction/microvascular pet-fusion/no-reflow引用本文复制引用
张冯迪..微血管损伤对急性心肌梗死患者的影响[J].临床与病理杂志,2017,37(6):1304-1309,6.基金项目
湖南省科技厅项目(2010FJ4086).This work was supported by the fund from Hunan Provincial Department of Science and Technology,China (2010FJ4086). （2010FJ4086）
