肺黏液表皮样癌的分子特征
Molecular features of pulmonary mucoepidermoid carcinoma
摘要
Abstract
Objective: To investigate the molecular characteristics of pulmonary mucoepidermoid carcinoma (PMEC). Methods: From July 2013 to December 2016, 13 PMEC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state.Results:EGFR mutation rate was 15.38% (2/13), and 2 cases were both L861Q point mutations, the relationship betweenEGFR gene status and gender (P=1.000), age (P=1.000), smoking (P=0.848) and stage (P=1.000) were no significant; the positive rate ofMAML2 fusion gene was 45.45% (5/11). the relationship betweenMAML2 fusion gene status and gender (P=0.521), age (P=0.521), smoking (P=1.000) and stage(P=0.924) were all no signiflcant. Conclusion:The most common form change of pulmonary mucoepidermoid carcinoma wasEGFR gene L861Q point mutation, MALM2 fusion gene exist in theEGFR gene wild type patients.关键词
肺黏液表皮样癌/分子特征/EGFR基因/MAML2基因Key words
pulmonary mucoepidermoid carcinoma/molecular features/EGFR gene/MAML2 gene引用本文复制引用
庄武,陈刚,王文娴,林雪平,黄韵坚,许春伟,陈燕坪,方美玉,朱有才,陆燕..肺黏液表皮样癌的分子特征[J].临床与病理杂志,2017,37(7):1382-1386,5.基金项目
国家临床重点专科建设项目(2013) （2013）
福建省科技厅引导性项目(2016Y0019) （2016Y0019）
福建省科技厅引导性项目(2015Y0011) （2015Y0011）
浙江省卫生科研计划基金(2013KYB051) （2013KYB051）
浙江省中医药局科研基金(2013ZQ005) （2013ZQ005）
浙江省科技厅公益类科研计划(2015C33194) （2015C33194）
吴阶平医学基金会临床科研资金项目(20114272111) （20114272111）
嘉兴市科技计划项目(2016AY23087) （2016AY23087）
嘉兴市科技局项目(2014AY21031-6).This work was supported by National Clinical Key Specialty Construction Program (2013) （2014AY21031-6）
Leading Project Foundation of Science Department of Fujian Province (2016Y0019) （2016Y0019）
Leading Project Foundation of Science Department of Fujian Province (2015Y0011) （2015Y0011）
Medical Scientific Research Foundation of Zhejiang Province (2013KYB051) （2013KYB051）
Zhejiang Administration of Traditional Chinese Medicine Foundation (2013ZQ005) （2013ZQ005）
The Science and Technology Planning Project of Zhejiang Province (2015C33194) （2015C33194）
Wu Jieping Medical Foundation Clinical Scientiflc Research Project (20114272111) （20114272111）
Science and Technology Plan Projects of Jiaxing of Zhejiang (2016AY23087) （2016AY23087）
Scientiflc and Technologic Bureau Projects of Jiaxing of Zhejiang (2014AY21031-6), China. （2014AY21031-6）
